Rare disease

【Product name】Lumina, HYDANTOL, PHENOBAL

[English common name]Phenobarbital

[Chinese common name]Phenobarbital

[English name]Phenobasone

[Chinese other name]Phenobarbital

[indications]
Compound phenobarbital sodium bromide tablets: calming the mind, relieving phlegm and calming. For all typesepilepsyWith neurosis.
Phenolbarbital scopolamine tablets: used to control symptoms of motion sickness such as dizziness, nausea and vomiting caused by riding, boat and aircraft.
Phenobarbital tablets: This product is mainly used to treat anxiety, insomnia (for patients with short sleep time), epilepsy and movement disorders. It is an important drug for the treatment of epileptic seizures and localized seizures. It can also be used as an anti-hyperbilirubinemia drug and before anesthesia.
Phenobarbital sodium injection: This product is effective for the treatment of epilepsy, both systemic and partial seizures, generallyPhenytoin, carbamazepine,Sodium valproateUse when invalid. It can also be used for convulsions and pre-anesthesia administration caused by other diseases.

【Dosage】
Compound phenobarbital sodium bromide tablets: Oral, 1-2 tablets at a time, 2-3 times a day.
Phenolbarbital scopolamine tablets: oral. Take 1 tablet at a time and take it 20 minutes before the ride.
Phenobarbital tablets: commonly used in adults: hypnosis, 30 ~ 100mg, once a night service; calm, once 15 ~ 30mg, 2 or 3 times a day; anticonvulsant, daily 90 ~ 180mg, can be served at night , or 30 ~ 60mg each time, three times a day; a maximum amount of 250mg, 500mg a day; anti-hyperbilirubinemia, once 30 ~ 60mg, three times a day. Commonly used in children: medication should be individualized, sedative, each weight 2mg/kg, or body surface area 60mg/m2, 2 to 3 times a day; anticonvulsant, each weight 3 ~ 5mg / kg; anti-biliary Redness, each time according to the weight of 5 ~ 8mg / kg, divided into oral, 3 to 7 days effective.
Sodium phenobarbital injection: intramuscular injection: anticonvulsant and status epilepticus, adult 100 ~ 200mg once, if necessary, can be repeated 4 to 6 hours. Pre-anesthesia administration: intramuscular injection of 100-200 mg 0.5 to 1 hour before surgery.

[Storage]
Compound phenobarbital sodium bromide tablets: sealed and kept in a cool dry place.
Phenolbarbital scopolamine tablets: sealed and preserved.
Phenobarbital tablets: sealed.
Sodium phenobarbital injection: sealed, stored in a cool dark place (not to exceed 20 ° C in the dark).

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

【Product name】REMICADE, Remicade

[English common name]Infliximab

[Chinese common name]Infliximab

[English name]

[Chinese other name]

[indications]
Rheumatoid Arthritis
This product is a disease-control anti-rheumatic drug. For patients with moderate to severe active rheumatoid arthritis, this product can be used in combination with methotrexate:
· Reduce symptoms and signs;
· Improve physical function and prevent disability in patients.
Crohn's disease
For patients with moderate to severe active Crohn's disease who are not well received by traditional treatment, this product can be used for:
· Reduce symptoms and signs;
· Achieve and maintain clinical efficacy;
· Promote mucosal healing;
· Improve the quality of life;
· Reduce the amount of corticosteroids or stop using corticosteroids.
Tracheal Crohn's disease
For patients with fistile Crohn's disease, this product can be used for:
Reduce the number of intestinal-cutaneous fistulas and rectal-vaginal fistulas to promote and maintain fistula healing;
· Reduce symptoms and signs;
· Improve the quality of life.
Ankylosing spondylitis
For patients with active ankylosing spondylitis, this product can be used for:
· Alleviate symptoms and signs, including increasing the range of activity;
· Improve physical function;
· Improve the quality of life.
psoriasis
For patients with psoriasis, this product can be used for:
Adult patients with chronic severe plaque psoriasis who require systemic treatment and are ineffective, contraindicated or tolerant to other systems such as cyclosporine, methotrexate or photochemotherapy. This product is intended for use only in patients who are treated under close supervision by a physician and regularly followed up by a physician.

【Dosage】
Usage: intravenous infusion.
Rheumatoid Arthritis
The product was administered 3 mg/kg for the first time, and then the same dose was administered once every 8 weeks after the second week and the sixth week after the first administration and thereafter. This product should be combined with methotrexate. For patients with poor efficacy, consider adjusting the dose to 10 mg/kg and/or adjusting the medication interval to 4 weeks.
Moderate and severe active Crohn's disease, fistula Crohn's disease
The product was administered 5 mg/kg for the first time, and then the same dose was administered once every 8 weeks after the second week and the sixth week after the first administration and thereafter. For patients with poor efficacy, consider adjusting the dose to 10 mg/kg.
Ankylosing spondylitis
The product was administered 5 mg/kg for the first time, and then the same dose was administered once every 6 weeks after the second week and the sixth week after the first administration and thereafter.
User guides
Sterility should be performed.
1. Calculate the dosage and determine the number of bottles used in this product: This product contains 100mg of infliximab per bottle, and calculate the total amount of the solution to be prepared.
2. Dissolve each bottle of medicine with 10 ml of sterile water for injection using a syringe equipped with a 21 gauge (0.8 mm) or smaller needle: remove the flip of the vial, wipe the top of the vial with a medical alcohol swab, and insert the syringe needle into the vial Cover, inject sterile water for injection. If the vacuum in the vial has been destroyed, the bottle cannot be used. Gently rotate the vial to dissolve the powder. Avoid shaking for a long time or with force. Do not oscillate. Foam may appear during the dissolution of the drug. After 5 minutes of storage, the solution should be colorless or light yellow, and the milk is white. Since infliximab is a protein, there may be some translucent particles in the solution. If opaque particles, discoloration or other substances appear in the solution, they cannot be used any more.
3. Dilute the sterile aqueous solution of this product to 250 ml with 0.9% sodium chloride injection: withdraw the same amount of liquid from the 250 ml 0.9% sodium chloride injection bottle or bag as the sterile injectable aqueous solution of this product. The sterile aqueous solution for injection of this product is completely injected into the infusion bottle or bag and gently mixed.
4. The infusion time should not be less than 2 hours: the infusion set should be equipped with a built-in, sterile, pyrogen-free, low protein binding filter (pore size ≤ 1.2 μm). Unused infusions should not be stored for further use.
5. The physical and biochemical compatibility studies of this product in combination with other drugs have not been carried out, and this product should not be infused simultaneously with other drugs.
Products administered parenterally should be visually inspected for the presence of particulate matter or discoloration prior to administration. If opaque particles, discoloration, or other foreign matter are found, the drug may not be used.
Plaque psoriasis
The product was administered 5 mg/kg for the first time, and then the same dose was administered once every 8 weeks after the second week and the sixth week after the first administration and thereafter. If the patient does not respond after week 14 (ie, after 4 doses), the product should not be treated.
Psoriasis patients re-administered
Patients with psoriasis have limited experience with a single administration after 20 weeks, suggesting a reduction in the effectiveness of the product compared to the initial induction therapy and an increase in mild to moderate infusion response.
After relapse of the disease, limited experience with repeated induction therapy showed an increase in infusion response (including severe reactions) compared to 8-week maintenance therapy.
If treatment interruption is maintained, it is not recommended to initiate induction therapy again and should be re-administered according to maintenance therapy.

[Storage]Store at 2-8 °C in the dark.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

【Product name】RAPAMUNE

[English common name]Sirolimus

[Chinese common name]Sirolimus

[English name]Rapamycin, Antibiotic AY 22989

[Chinese other name]Rapamycin, antibiotic

[indications]
Sirolimus capsule: It can be used for the treatment of organ transplant anti-rejection and autoimmune diseases.
Sirolimus: Rapamune is suitable for patients undergoing kidney transplantation to prevent organ rejection. It is recommended that Rapamune be used in combination with cyclosporine and corticosteroids.
Oral solution of sirolimus: suitable for patients undergoing kidney transplantation to prevent organ rejection.

【Dosage】
Sirolimus capsules: Oral. A single loading dose of 6 mg followed by a maintenance dose of 2 mg/day.
Sirolimus: Rapamo is intended for use by immunotherapists and physicians who have experience in treating kidney transplant patients. Patients receiving this drug should be treated in an institution equipped with appropriate laboratories and ancillary medical facilities and personnel. The physician responsible for maintaining the treatment should have complete information necessary for patient follow-up. It is recommended that rapazone tablets be used in combination with cyclosporine and corticosteroids. Repa is used orally, once a day, with or without food. Since the bioavailability of tablets after crushing, chewing or incision has not been determined, such a method of use is not recommended. Oral solutions should be prescribed for patients who cannot take tablets and instructions should be used. Rapai should be taken as soon as possible after transplantation. It is recommended that the use of Repaming should be taken with cyclosporine oral solution (modified) and / or cyclosporine capsule (modified).
Oral solution of sirolimus: It is recommended that the oral solution of sirolimus be combined with cyclosporine and corticosteroids. On the first day, the single dose of 6mg was loaded, 2mg/day in 2 weeks (reduced adverse reactions), and 1-2mg/day after 2 weeks. In order to minimize the difference in absorption of the drug, the drug should be taken with or without food. Grapefruit juice can slow the metabolism of sirolimus regulated by CYP3A4 and therefore cannot be used to deliver or dilute the oral solution of sirolimus. It is recommended to take sirolimus 4 hours after taking cyclosporine oral solution (microemulsion) and/or cyclosporine capsule (microemulsion). The starting dose of patients with a dose-adjusted age of 13 years or older but weighing less than 40 kg should be adjusted according to the body surface area at 1 mg/m2/day, and the dose should be 3 mg/m2.

[Storage]
Sirolimus capsule: sealed, moisture-proof.
Sirolimus tablets: shading, confined preservation.
Sirolimus oral solution: sealed.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

【Product name】Coenzyme

[English common name]Coenzyme Q10

[Chinese common name]Coenzyme Q10

[English name]Natural quinone, Ubiquinone 10

[Chinese other name]Terpene, ubiquinone 10

[Indications] This product is used for adjuvant treatment of the following diseases:
1, cardiovascular diseases, such as: viral myocarditis, chronic heart failure.
2, hepatitis, such as: viral hepatitis, subacute liver necrosis, chronic active hepatitis.
3, comprehensive treatment of cancer: can alleviate some adverse reactions caused by radiotherapy, chemotherapy and so on.

[Usage and Dosage] 1 tablet (granule) at a time, 3 times a day, taken after meals.

[Storage] sealed, moisture-proof.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.