Valproic acid

【Product name】DEPACON, DEPAKENE, VALERIN

[English common name]Valproic Acid

[Chinese common name]Valproic acid

[English name]Mylproin, Ergenyl

[Chinese other name]2-propyl valeric acid, A-propyl valeric acid

[indications]
Sodium valproate for injection: This product is used for treatmentepilepsyIn adults and children, when it is temporarily not possible to take oral dosage forms, it is used to replace oral dosage forms.
Sodium valproate sustained-release tablets: for the treatment of systemic and partial seizures, as well as special types of syndromes.
1. Systemic epilepsy applies to: absence seizures, myoclonic seizures, tonic-clonic seizures, tonic seizures, and mixed seizures.
2. Partial epilepsy applies to: simple partial seizures; complex partial seizures; partial secondary systemic seizures.
3. Special type syndrome: West,Lennox-Gastaut syndrome.

【Dosage】
Sodium valproate for injection: for temporary replacement (for example, waiting for surgery): intravenous administration after 4 to 6 hours of oral administration, the intravenous injection of this product is dissolved in 0.9% normal saline, or continuous intravenous infusion over 24 Intravenous infusions are administered four times a day, or over a maximum dose range (usually an average dose of 20 to 30 mg/kg/day), for more than one hour each time. Need to quickly reach the effective blood concentration and maintain: slow intravenous bolus injection at a dose of 15mg / kg, more than 5 minutes; then intravenously drip at a rate of 1mg / kg / hr, so that the plasma sodium valproate concentration reached 75mg / L, and Adjust the infusion rate according to the clinical situation. Once the intravenous infusion is stopped, it should be administered orally immediately to supplement the active ingredient. The oral dose can be used in the previous or adjusted dose, or as directed.
Sodium valproate sustained-release tablets: The daily dose should be determined according to the age and weight of the patient, and the wide individual sensitivity to valproic acid should be considered. The relationship between daily dose, serum concentration and efficacy has not been established. The optimal dose should be determined according to the clinical response: when the seizure cannot be controlled or suspected to have side effects, in addition to clinical monitoring, the determination of the plasma concentration of sodium valproate should be considered. The effective range has been reported to be 40-100 mg/l ( 300-700 μmol/l).
1. Initial treatment administration method (oral):
(1) In patients who did not receive other antiepileptic drugs, the drug dose was increased every 2-3 days, and the optimal dose was reached within 1 week.
(2) In patients who have previously received other anti-epileptic drugs, this product should slowly increase the dose and reach the optimal dose within 2 weeks.

[Storage]
Sodium valproate for injection: sealed.
Sodium valproate sustained-release tablets: sealed and placed in a cool place.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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Product information

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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    [Chinese common name]Sodium valproate

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    [indications]
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    【Dosage】
    Sodium valproate tablets:
    Adults commonly used: daily weight 15mg / kg or 0.6-1.2g (3-6 tablets) per day 2-3 times. Start with 5-10mg/kg, and increase it after one week until it can control the seizure. When the daily dosage exceeds 250mg, it should be taken in divided doses to reduce gastrointestinal irritation. The maximum daily dose is no more than 30mg/kg by weight, or 1.8-2.4g (9-12 pieces) per day. Commonly used in children: the same as adults, can also be 20-30mg/kg per day, divided into 2-3 times or 15mg/kg per day, increase by 5-10mg/kg every other week, to be effective or not Tolerance.
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    2 pediatric commonly used amount: the same as adults by weight. It has also been reported that at the beginning, the body weight is 15 mg/kg, and 5 to 10 mg/kg is added every other week as needed until it is effective or not tolerated.

    [Storage]
    Sodium valproate tablets: sealed and stored in a dry place.
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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.