Tofatinib

【Product name】Xeljanz

[English common name]Tofacitnib

[Chinese common name]Tofatinib

[English name]

[Chinese other name]

[Indications] XELJANZ, an inhibitor of Janus kinase (JAKs), is indicated for the treatment of moderate to severe activityRheumatoid arthritisAdult patients have not responded well or are intolerant to methotrexate. It can be used as a monotherapy or in combination with methotrexate or other non-biological disease modifying antirheumatic drugs (DMARDs). XELJANZ should not be combined with biological products DMARD or strong immunosuppressive agents such as azathioprine and cyclosporine.

[Usage and dosage] rheumatoid arthritis
Tofacinix can be used in combination with methotrexate or other non-biological DMARD drugs. The recommended dose for Tofacinix is 5 mg twice daily. Oral administration, with or without food.
Dose adjustment for severe infection and cytopenia is not recommended in patients with absolute lymphocyte counts below 500 cells/mm3, absolute neutrophil counts (ANC) below 1000 cells/mm3, or hemoglobin levels below 9 g/dL. Start Tofacinix medication.
In the case of lymphopenia, neutropenia, and anemia, it is recommended to adjust the dose or discontinue treatment.[See notes and adverse reactions]
If the patient has a serious infection, Tofacinix should be avoided until the infection is controlled.
Dose adjustment due to drug interactions in the following patients:
It is also treated with a potent inhibitor of cytochrome P450 3A4 (CYP3A4) (such as ketoconazole) or one or more combined drugs (such as fluconazole) that can cause both moderate inhibition of CYP3A4 and potent inhibition of CYP2C19. The recommended dose for Tofacinix should be 5 mg once daily.
Combinations of Tofacinix with potent CYP3A4 inducers (such as rifampicin) may result in loss or decline in clinical remission. A potent CYP3A4 inducer is not recommended for combination with Tofacinix.
Dosing adjustment for patients with renal or hepatic impairment
Among the following patients:
Moderate or severe renal insufficiency, or moderate liver damage, Tofacinix recommended dose should be 5 mg once daily. Tofacinix is not recommended for patients with severe liver damage.

[Storage]Store in a cool dry place, no more than 30 ° C. Protect from light and avoid contact with children.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.