Pirfenidone

【Product name】Pirfenex, Esbriet

[English common name]Pirfenidone

[Chinese common name]Pirfenidone

[English name]

[Chinese other name]

[indications]
1. Idiopathic pulmonary fibrosistranssexual
Idio-pathic pulmonary fibrosis (IPF) is a chronic inflammatory interstitial lung disease with unknown causes, poor prognosis, and high mortality. PFD is an anti-inflammatory, anti-fibrotic preparation that can be used in the treatment of IPF.
2. Liver fibrosis
3. Renal fibrosis
4.Multiple sclerosis
Multiple sclerosis (MS) is an inflammation and demyelinating disease associated with the central nervous system and immunity. The immune factors associated with it are the activation of stellate cells, glia cells, endothelial cells and the increase of lymphocytes, while PFD has the property of inhibiting cell activation.
5. Myocardial tissue fibrosis
Cardiovascular diseases such as hypertension, cardiomyopathy, and atrial fibrillation can cause fibrosis of myocardial tissue, which in turn can worsen or develop the disease. Treatment of progressive pseudohypertrophic muscular dystrophy with PFDcardiac diseaseIt can inhibit myocardial fibrosis and improve heart function. PFD reduces myocardial remodeling and atrial fibrillation by inhibiting fibrosis.
6. Neoplastic diseases:Neurofibroma, uterine leiomyoma, malignant glioma.
7. Prevention of fibrosis after organ transplantation
8.Rheumatoid arthritis

[Usage and Dosage] This product gradually increases the dosage according to the principle of increasing dose. When taking this product on an empty stomach, the concentration of pirfenidone in the blood will increase significantly, and side effects may occur, so it is appropriate to take it after meals. The initial dosage of this product is 200mg each time, 3 times a day. It is hoped that by increasing the dose of 200mg every time in two weeks, the dosage of this product will be maintained at 600mg (1800mg per day); it should be closely observed. Patients with medication tolerance, if there are obvious gastrointestinal symptoms, skin reactions to sunlight or UV light, significant changes in liver function enzymes and weight loss, you can reduce the dose according to clinical symptoms or stop taking the drug, in the symptoms After the reduction, the dosage can be gradually increased, and it is preferable to adjust the maintenance amount to 400 mg (1200 mg per day) or more.

[Storage] Store at 15-30 ° C; (59-86 ° F).

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

Description

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product manual

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Product information

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.