Tombuzumab

【Product name】ACTEMRA

[English common name]TocilizumabInjection

[Chinese common name]Tocilizumab injection

[English name]Tocilizumab

[Chinese other name]

[Indications] for moderate to severe-activity of poor response to one or more TNF antagonistsRheumatoid arthritisAdult patient.

[Usage and dosage] Rheumatoid arthritis. ACTEMRA can be used alone or in combination with methotrexate or other DMARDs.
1. Adult recommended dose every 4 weeks: Patients do not respond well to one or more TNF antagonists: when used in combination with DMARD or monotherapy, the recommended starting amount is 4 mg/kg and then increased to 8 based on clinical response. Mg/kg. Patients with neutrophil absolute count (ANC) below 2000/mm3, platelet counts below 100,000/mm3, or ALT or AST above 1.5 times the upper limit of normal (ULN) are advised not to start with ACTEMRA.
2. It is recommended that the dose of ACTEMRA should not exceed 800 mg per infusion.
3. Administration for intravenous infusion is diluted with sterile to 100 mL of 0.9% sodium chloride. A single intravenous drip during 1 hour. Don't push.
4. Adjust dose recommendations for certain dose-related laboratory changes including elevated liver enzymes, leukopenia, and thrombocytopenia.

[Storage] Store in the refrigerator (2 ° C - 8 ° C). Do not freeze. Place the pre-installed syringe in the outer carton to prevent light and moisture.

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