New Drug Corresponding Disease

Idiopathic pulmonary hypertension , scleroderma

Bosentan

【Product name】Tracleer

[English common name]BOSENTAN

[Chinese common name]Bosentan

[English name]

[Chinese other name]

[Indications] for the treatment of patients with stage III and IV primary pulmonary hypertensionpulmonary hypertension,orsclerodermaCaused by high blood pressure in the lungs.

[Usage and Dosage] The initial dose of hollyli is 22.5 times a day, 62.5 mg each time for 4 weeks, then increased to a maintenance dose of 125 mg twice a day, twice a day, twice a dose of 125 mg There is no benefit that is sufficient to offset the risk of liver damage. You can take all-profit in the morning and evening before or after eating.
1. Patients with impaired renal function: Impaired renal function has little effect on the pharmacokinetics of Quancoli and does not require dose adjustment.
2. Elderly: All-Korean clinical studies did not include enough patients aged 65 years and older to determine if their response was the same as in young patients. Usually, because of kidney and/or heart function decline, there is With the disease, other drug treatment, especially liver function is reduced, so the dose of elderly patients should be carefully selected.

[Storage] sealed and stored.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Acromegaly , Acromegaly

Bromocriptine

【Product name】Parlodel

[English common name]Bromocriptine

[Chinese common name]Bromocriptine

[English name]

[Chinese other name]

[indications]
1. Endocrine system diseases: prolactin-dependent menstrual cycle disorders and infertility (with high or normal prolactinemia), amenorrhea (with or without lactation), less menstruation, luteal function and drug-induced High prolactinosis (antipsychotics and treatments for hypertension).
2. Non-prolactin-dependent infertility: polycystic ovary syndrome, combined with anti-estrogen (such as: chloralamine) for anovulation.
3. Hyperprolactinoma: Conservative treatment of small pituitary adenomas, inhibiting adenoma growth or reducing the volume of adenoma before surgery, making excision easy; postoperative can be used to reduce the still higher prolactin levels.
4.Acromegaly: Application alone or in combination with radiotherapy, surgery, etc. can reduce plasma levels of growth hormone.

[Usage and Dosage] should be taken orally at mealtime
1. Irregular menstrual cycle and infertility: According to the need, l/2 tablets (1.25mg with bromocriptine mesylate), 2-3 times a day, if necessary, the dose can be increased to 1 tablet (with A Bromocriptine sulfonate 2.5mg), 2 to 3 times a day. Treatment should be continued until the menstrual cycle returns to normal and/or re-ovulation. If necessary, several cycles of treatment can be continued to prevent recurrence.
2. High prolactinosis: 1/2 tablet (1.25mg with bromocriptine mesylate), 2-3 times a day, gradually increased to 4-8 tablets per day (with methanesulfonic acid) Bromocriptine 10-20mg), the specific program should be based on clinical efficacy and side effects.
3. Acromegaly: The recommended starting dose is 1-1.5 tablets a day.

[Storage] The container is stored in a carton in the outer packaging (15-25 ° C). In the tropics, the container is placed in an outer carton and sealed to protect it from light and moisture.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Multiple sclerosis , Multiple sclerosis

Triflurane

【Product name】Aubagio

[English common name]Teriflunomide

[Chinese common name]Triflurane

[English name]Teriflunomide [INN], Active metabolite of leflunomide

[Chinese other name]

[Indications] AUBAGIO is a pyrimidine synthesis inhibitor suitable for use inMultiple sclerosisTreatment of relapsing patients.

[Usage and Dosage] 7mg or 14mg orally once a day, with or without food.

[Storage] The drug does not require any special storage conditions.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Osteoporosis in postmenopausal women

Denosem

【Product name】Prolia

[English common name]Denosumab

[Chinese common name]Denosem

[English name]Xgeva

[Chinese other name]

[indications] for treatmentOsteoporosis(a disease that makes bones weak).

[Usage and Dosage] Pululia is given every six months, and 60 mg (belly) or the back of the arm is injected under the skin of the thigh and abdomen. During the treatment with Prolia, the doctor should ensure that the patient receives calcium and vitamin D supplements. Prolia can be provided by trained people on how to properly inject.

[Storage] Store in the refrigerator (2 ° C – 8 ° C). Do not freeze. Keep the container in the outer box to protect it from light.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
asthma

Cyclosporine

【Product name】Zetonna, ALVESCO, Alvesco HFA

[English common name]Ciclesonide

[Chinese common name]Cyclosporine

[English name]

[Chinese other name]

[indications]As a preventive treatment for adults and ≥ 12 year oldsasthmaMaintenance therapy for the patient.

【Dosage】For the maintenance of asthma in adults and children, the lowest dose for adolescents and adults over 12 years old >80-160ug, medium dose >160-320ug, higher dose >320ug; the lowest dose for children 6-11 years old 80ug, medium dose >80-160ug The higher dose is >160ug; the minimum maintenance dose for children aged 5 and under is 160ug.

[Storage] Always keep the nasal spray clean and dry. Store the drug between 59° and 86°F. Do not freeze. Keep out of reach of young children.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Colorectal cancer (CRC)

Rigofini

【Product name】Stivarga

[English common name] Rigofini

[Chinese common name] Reggiofinia

[English name]

[Chinese other name]

[indications]
1. It is suitable for the treatment of previous chemotherapy based on fluorouracil, oxaliplatin and irinotecan, as well as metastasis which has been or is not suitable for anti-VEGF therapy and anti-EGFR therapy (RAS wild type).Colon cancer (mCRC)patient.
2. Locally advanced, inoperable or metastatic, previously treated with imatinib mesylate and sunitinib malateGastrointestinal stromal tumor (GIST)patient.

【Dosage】The recommended dose is 160 mg (4 tablets, each containing 40 mg regorafenib) once daily for oral administration for the first 21 days of each course of treatment and 28 days for one course of treatment.

[Storage]Store below 25 ° C. Keep medicines out of reach of children. The desiccant is used in the cap to prevent accidental eating. Keep the cap closed to avoid heat and humidity.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
epilepsy

Retigabine

【Product name】Retigabine

[English common name]Ezogabine

[Chinese common name]Retigabine

[English name]R189051

[Chinese other name]Retitapine

[indications]Adult partepilepsyAdjuvant therapy for seizures.

【Dosage】The initial dose is 100 mg three times a day (300 mg daily). Based on individualized patient response and tolerance, gradually increase the dosage, no more than 50 mg 3 times a day (dos not increase more than 150 mg / day) to a maintenance dose of 200 mg to 400 mg 3 times a day (600 mg to 1200 mg / day), the interval between dose changes should be no less than one week. Clinical trials have shown that 400 mg daily for 3 times shows an increase in adverse effects, and a dose of 300 mg daily 3 doses is safer and more effective than 400 mg 3 times daily (1200 mg daily).

[Storage]Low temperature

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Hodgkin's disease , Multiple myeloma

Methyl benzamidine

【Product name】MATULANE

[English common name]Procarbazine

[Chinese common name]Methyl benzamidine

[English name]

[Chinese other name]

[indications]
1. Hodgkin's disease: can make 1/3 to 1/2 patients completely relieved, andNitrogen mustard,VincristineThe MOPP program consisting of prednisone is one of the basic programs for the treatment of Hodgkin's disease.
2. RightHodgkin's lymphomaMalignant histiocytosis (malignant histiocytosis), mycosis fungoides (sputum granuloma),Multiple myeloma,Melanoma,Brain tumorEtc. also has a certain effect.
3. In combination with radiotherapy, treatment shows a beneficial effect on radiation-resistant bronchial adenocarcinoma.

【Dosage】
1. Oral: 150 to 300 mg per day, divided into 3 to 4 times, or 150 to 200 mg before bedtime, even for 2 weeks, repeated after 4 weeks, the total dose of one course depends on the blood, usually 7 ~ 9g . When the MOPP regimen is used to treat Hodgkin's disease, it is 100 mg/m2 per day for 14 days.
2. Intravenous infusion: 2 ~ 7mg / kg, gradually increased from the lower dose, a total of 7 ~ 10g a course of treatment.

[Storage]Store at room temperature, sealed, and protected from light.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Homozygous familial hypercholesterolemia (HoFH)

Lomestatin mesylate

【Product name】Lojuxta

[English common name]Lomitapide

[Chinese common name]Lometa is a mesylate

[English name]Capsule 28capsule

[Chinese other name]

[indications]Homozygous familial hypercholesterolemia(HoFH).

【Dosage】
(1) Before treatment, measure ALT, AST, alkaline phosphatase, and total bilirubin; negative fertility test in women with fertility; and start a low-fat diet from fat supply energy <20%.
(2) Start treatment at 5 mg once a day. Adjust the dose according to Ken's safety/tolerance: increase to 10 mg per day after at least 2 weeks; and then, at a minimum 4-week interval, to 20 mg, 40 mg, and up to a maximum recommended dose of 60 mg per day.
(3) Reduced absorption of fat-soluble vitamins/fatty acids: daily intake of vitamin E, linoleic acid, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) Supplement.
(4) Take 1 time a day, with water and no food, at least 2 hours after dinner.
(5) Patients with end-stage renal disease who have dialysis should have a baseline mild liver damage of no more than 40 mg per day.

[Storage] Storage temperature is lower than 30 °C. Keep the bottle tightly closed to prevent moisture.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Breast cancer

Eriblin mesylate

【Product name】Halaven

[English common name]Eribulin

[Chinese common name]Eriblin mesylate

[English name]Eribulin Mesilate

[Chinese other name]Erebrin mesylate

[Indications] for the treatment of metastasis that has been treated with at least 2 chemotherapy regimensBreast cancerPatients, and the chemotherapy regimen should include an anthracycline or a taxane.

【Dosage】Eribulin mesylate was dissolved in a 5% by volume aqueous solution of ethanol at a concentration of 0.5 g/mL, usually at a dose of 21 days (1 day): 1.4 mg at 1 d and 8 d M2, intravenous injection lasted 2-5 min.

[Storage] From a microbiological point of view, the product should be used immediately unless the opening method eliminates the risk of microbial contamination. If not used immediately, the storage time and conditions in use are the responsibility of the user.
If HALAVEN is not used immediately as an undiluted solution in a syringe, it should not be stored for more than 4 hours at 25 ° C and ambient light, or 24 hours at 2 ° C – 8 ° C.
A diluted solution of HALAVEN (0.018 mg / ml to 0.18 mg / ml eribulin in sodium chloride 9 mg / ml (0.9%)) should not be stored at 2 ° C – 8 ° C for more than 24 hours unless Dilution is carried out under controlled and effective aseptic conditions.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Chronic myelogenous leukemia (CML) , Chronic myeloid leukemia

Busulfan

[product name] Myleran, Busilvex, Busulfex Bai Shufei

[English common name]busulfan

[Chinese common name] Bai Xiaoan

[English name]Busulphan, Tetramethylene bis(methanesulfonate)

[Chinese other name]Malilan, White Blood Fuen

[indications]
Bai Xiao'an tablets: This product is mainly suitable forChronic myeloid leukemiaThe chronic phase is not effective for patients with a lack of Philadelphia chromosome Ph1. It can also be used to treat essential thrombocytosis.Polycythemia veraSuch as chronic myeloproliferative diseases.
Baixiao'an injection: This product is suitable for combined with cyclophosphamide as a pretreatment protocol for hematopoietic progenitor cells of chronic myeloid leukemia.

【Dosage】
Baixiao'an tablets: This product is commonly used in adults: chronic myeloid leukemia, total daily 4 ~ 6mg / m2, once a day. If the number of white blood cells drops to 20 × 109 / L, it is necessary to stop the drug as appropriate. Or give a maintenance amount of 1 to 2 mg per day or every other day to maintain a white blood cell count of about 10 × 109 / L.
Baixiao'an injection: This product should be administered through the central venous catheter. Each dose requires infusion for 2 hours, and every 6 hours for 4 consecutive days, a total of 16 times.

[Storage]
Buchanan tablets: sealed and kept in a cool place.
Baixiao'an injection: 2 ° C ~ 8 ° C

【Tips】Part of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctor's face diagnosis. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Hyponatremia

Konnivatan hydrochloride

【Product name】Vaprisol, Conivaptan

[English common name]Conivaptan

[Chinese common name]Konnivatan hydrochloride

[English name]Conivaptan hydrochloride

[Chinese other name]

[Indications] Cognava hydrochloride is mainly used for normal blood volume.Hyponatremia(often associated with patients with antidiuretic hormone abnormal secretion syndrome,thyroidTreatment of hospitalized patients with hypofunction, patients with adrenal insufficiency or patients with lung disease.

[Usage and Dosage] Vaprisol (Kaunavatan Hydrochloride Injection) is 4ml: 20mg, generally stored at 15 ~ 30 ° C protected from light (can not be stored in the environment below 15 ° C). Vaprisol can only be administered via the large vein. It is recommended to change the injection site once a day to reduce the possible vascular irritation. Vaprisol can only be diluted with 5% dextrose injection, not for lactated Ringer's injection or saline.
At the time of loading dose administration, 4 ml: 20 mg, ornidantan hydrochloride injection, was added and administered to 100 ml of 5% dextrose injection for at least 30 minutes. At the time of maintenance dosing, 4 ml (20 mg) of cognavadine injection was administered and administered to 250 ml of 5% dextrose injection for 24 hours.

[Storage] Store at 25 ° C (77 ° F); allowable temperature is 15 – 30 ° C (59 – 86 ° F), room temperature control (according to USP). Do not store below 15 ° C (59 ° F). Ampoules should be stored in cardboard containers protected from light until ready for use.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.