药品库-罕见病-香港环球医药贸易有限公司

Crohn's disease

Tacros

【Product name】Putti, Envarsus, MODIGRAF, PROGRAF, Tacrolimus, ASTAGRAF

[English common name]Tacrolimus

[Chinese common name]Tacros

[English name]Big ring piperon, Taikelima

[Chinese other name]Macrocyclic melam, texley horse

[indications]
Tacrolimus Sustained Release Capsule: Prevents graft rejection after liver or kidney transplantation.
Tacrolimus injection:
1. Prevention of graft rejection after liver or kidney transplantation.
2. Treatment of graft rejection after liver or kidney transplantation using other immunosuppressive drugs.
Tacrolimus ointment: This product is suitable for patients with moderate to severe atopic dermatitis who are not suitable for traditional treatment due to potential risks, or who have not responded to traditional therapies or cannot tolerate traditional therapy, as short-term or intermittent long-term treatment. .
Tacrolimus capsule: Prevents graft rejection after liver or kidney transplantation.

【Dosage】
Tacrolimus Sustained Release Capsules:
1. Recommended starting dose for oral administration of Prograf in adults after surgery:
(1) For patients with liver transplantation, the initial oral dose should be 0.1-0.2 mg/kg per day by weight, taken orally twice, and started 6 hours after surgery.
(2) For kidney transplant patients, the initial oral dose should be 0.15-0.3 mg/kg per day by weight, divided into two orally, and the drug should be started within 24 hours after surgery.
2. Rejection that is ineffective against traditional immunosuppressive therapy:
(1) For patients with rejection and traditional immunosuppressive therapy, patients should start treatment with Prograf. The recommended starting dose is the same as the level of first immunosuppressive agent.
Tacrolimus injection: The following recommended doses for oral and intravenous administration are only general indicators. The actual dose of the drug should be adjusted according to the needs of individual patients. The recommended dose is only the initial dose, so the treatment should be The clinical judgment was supplemented with monitoring of the concentration of tacrolimus in the blood to adjust the dose.
1. Oral administration: The daily dose is administered in two divided doses. It is best to take capsules on an empty stomach or at least 1 hour before eating or 2-3 hours after eating to achieve maximum absorption. Oral capsules are usually administered continuously to inhibit transplant rejection and have no limitations during treatment.
2. Intravenous administration:
(1) The concentrate for infusion must be diluted with 5% glucose or physiological saline in polyethylene or glass bottles.
Tacrolimus ointment:
1. Adult 0.03% and 0.1% tacrolimus ointment Apply a thin layer of this product on the affected area, gently rub it, and cover it completely, twice a day, until the atopic dermatitis symptoms and signs disappear one week. Encapsulation therapy may promote systemic absorption and its safety has not been evaluated. This product should not be used for external application of package dressings.
2. Children 0.03% tacrolimus ointment Apply a thin layer of this product on the affected area, gently rub it, and cover it completely, twice a day, until a week after the disappearance of atopic dermatitis symptoms and signs. Encapsulation therapy may promote systemic absorption and its safety has not been evaluated. This product should not be used for external application of package dressings.
Tacrolimus capsule:
1. Recommended starting dose for oral administration of Prograf in adults after surgery:
(1) For patients with liver transplantation, the initial oral dose should be 0.1-0.2 mg/kg per day by weight, taken orally twice, and started 6 hours after surgery.
(2) For kidney transplant patients, the initial oral dose should be 0.15-0.3 mg/kg per day by weight, divided into two orally, and the drug should be started within 24 hours after surgery.
2. Rejection that is ineffective against traditional immunosuppressive therapy:
(1) For patients with rejection and traditional immunosuppressive therapy, patients should start treatment with Prograf. The recommended starting dose is the same as the level of first immunosuppressive agent.
(2) The patient is converted from cyclosporine to prograf, and the first dose interval of Prograf is no more than 24 hours.

[Storage]
Tacrolimus Sustained Release Capsules: sealed, stored in a cool, dry place.
Tacrolimus injection: shading, sealed and preserved.
Tacros ointment: sealed.
Tacrolimus capsule: sealed, placed in a cool place.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
X interlocking ichthyosis

Tazarotene
other

Oral live vaccine for type 4 and type 7 adenovirus

【Product name】Ardovax

[English common name]Adenovirus types 4 and 7 live

[Chinese common name]Oral live vaccine for type 4 and type 7 adenovirus

[English name]

[Chinese other name]

[indications]

【Dosage】

[Storage]

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Music is

[English common name] Tazarotene

[Chinese common name] Tazarotene

[English name]

[Chinese other name]

[Indications]
Tazarotene gel: This product is suitable for the treatment of
glaucoma

Fluprostin

【Product name】Zioptan

[English common name]Tafluprost ophthalmic

[Chinese common name]Fluprostin

[English name]Tafluprost

[Chinese other name]Fluoroprost

[indications]Open angle type for patients with reduced intraocular pressureglaucomaOr high ocular hypertension.

【Dosage】The recommended dose is one drop of conjunctival sac in the eye, once a day, at night. The dose should not exceed once a day as it has been shown that frequent administration of prostaglandin analogues may reduce the effects of decreased intraocular pressure.

[Storage]Sealed and stored at 2-8 ° C (36-46 ° F). Store in the original pouch. Once the pouch is opened, the disposable container can be stored in an open foil pouch for up to 28 days at room temperature: 20-25 ° C (68-77 ° F). Moisture proof. Make a note of the date the aluminum foil bag was opened in the space provided on the pouch. Discard any unused containers 28 days after opening the bag for the first time.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
pulmonary hypertension

Tadalafil

【Product name】Cialis

[English common name]Tadalafil

[Chinese common name]Tadanafil

[English name]IC-351

[Chinese other name]Hedi

[indications] erectile dysfunction andpulmonary hypertension.

[Usage and Dosage] The recommended dose of this product is 10mg. It is taken before sexual life and is not affected by eating. If the effect of taking 10mg is not significant, you can take 20mg. It can be taken at least 30 minutes before sex. The maximum frequency of medication is Once a day.

[Storage] Store at room temperature.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
血小板减少症

Equippa

【Product name】Promacta

[English common name]Equippa

[Chinese common name]Equippa

[English name]

[Chinese other name]

[Indications] Chronic immunity (idiopathic) in adults and pediatric patients over 1 year old Thrombocytopenia (ITP)

[Usage and Dosage] Fasting (1 hour or 2 hours after a meal), daily adult and pediatric patients over 6 years old start PROMACTA 50 mg daily, 25 mg per day for pediatric patients between 1 and 5 years old. Patients with liver damage and patients of East Asian descent require a dose reduction. Adjust to maintain a platelet count greater than or equal to 50 x 10 9 / liter. Do not exceed 75 mg per day.

[Storage] Store at room temperature between 20 ° C and 25 ° C (68 ° F to 77 ° F); allow tours to 30 ° C (59 ° F to 86 ° F). Do not remove desiccant if present. Exempt the original bottle.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Glutamine

Yiyi Maibu

【Product name】Zetia

[English common name]Ezetimibe

[Chinese common name]Yiyi Maibu

[English name]ZETIA, Ezetimibe

[Chinese other name]Etimibe, ezetimibe

[indications]
(1) Hypercholesterolemia After the conventional dose of statin treatment, the cholesterol level is still not up to standard;
(2) Unsuitable or intolerant of statins in the treatment of patients with hypercholesterolemia;
(3) patients with severe hypercholesterolemia can be directly combined with ezetimibe and small and medium dose statins;
(4)Homozygous familial hypercholesterolemiapatient;
(5) combined with fenofibrate for mixed dyslipidemia with triglyceride elevation as the main manifestation;
(6) in combination with small and medium dose statins for patients with chronic kidney disease;
(7) Application of ezetimibe alone or in combination with statins for primary or secondary prevention of coronary heart disease.

【Dosage】Patients should adhere to a proper low-fat diet during the treatment of this product. The recommended dose of this product is once a day, 10mg each time, can be taken alone or in combination with statins. This product can be taken at any time within 1 day, can be taken on an empty stomach or at the same time as food. Older patients do not need to adjust the dose. Children and adolescents over the age of 10 do not need to adjust the dose. This product is not recommended for children younger than 10 years old. Patients with mild hepatic impairment do not need to adjust the dose (Child-Pugh score at 5 or 6) (see pharmacokinetics). Patients with impaired renal function do not need to adjust the dose. Use with a bile acid sequestrant: Take this product more than 2 hours before taking the bile acid chelating agent or more than 4 hours after taking it.

[Storage] shading, sealed storage (30°C)

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Breast cancer

Ixapilone

【Product name】Ixempra

[English common name]Ixabepilone

[Chinese common name]Ixapilone

[English name]Ipsapironum

[Chinese other name]1-dioxide

[Indications] IXEMPRA combined with capecitabine for the treatment of metastatic or local advancedBreast cancerPatients who are resistant to anthracyclines and taxanes, or whose cancers have taxane resistance and are further contraindicated for their anthracycline treatment. Anthracycline resistance is defined as the progressive metastatic environment during treatment or within 6 months or within 3 months of the adjuvant treatment group. Taxane resistance is defined as progression at treatment or within 12 months of adjuvant therapy or at 4 months in a metastatic environment.
IXEMPRA is indicated for the treatment of advanced breast cancer anthracyclines, taxanes and capecitabine in patients with metastatic or local monotherapy tumor-resistant or refractory patients.

[Usage and Dosage] The recommended dose of IXEMPRA is 40 mg / m 2 and intravenous administration for 3 hours every 3 weeks. The dose of a patient with a body surface area (BSA) greater than 2.2 m2 should be calculated according to 2.2 m2.

[Storage] The IXEMPRA kit must be stored in a refrigerator at 2 ° C to 8 ° C (36 ° F to 46 ° F). Keep the original packaging until it is used to prevent light.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
scleroderma

Iloprost

【Product name】CellCep

[English common name]Mycophenolate mofetil

[Chinese common name]Mycophenolate mofetil

[English name]Mycophenolate mofetil

[Chinese other name]Mycophenolate mofetil

[Indications] treatment of moderate primarypulmonary hypertension.

[Usage and Dosage] Adult: Each inhalation should start from 2.5 micrograms (the dose provided by the mouthpiece in the inhalation device). The dose of iloprost can be gradually increased to 5.0 micrograms depending on the needs and tolerance of different patients.
According to the needs and tolerance of different patients, iloprost should be inhaled 6-9 times a day.
Depending on the dose of drug required for the mouthpiece and nebulizer, each inhalation time should be approximately 5-10 minutes.
Patients with renal function or hepatic insufficiency: patients with abnormal liver function and renal failure requiring hemodialysis, the clearance rate of iloprost is reduced, and the dosage should be considered.
Children and adolescents (under 18 years of age): There is currently no experience in children or adolescents. This medicine cannot be used in patients under the age of 18 unless it is supported by the data.
Use of nebulizer: If a nebulizer meets the following criteria, it is considered to be suitable for atomization of the drug solution: the median aerodynamic diameter (MMAD) or median diameter (MMD) of the droplet is 3 -4m; oral output dose: 2.5 or 5 ug per inhalation of iloprost; atomization time of 2.5 or 5 ug of iloprost: approximately 4-10 minutes (to avoid systemic side effects, 4 The iloprost output in minutes must not exceed 5ug).

[Storage]Shading and confined storage.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Osteoporosis in postmenopausal women

Ibandan sodium

[product name] BONIVA

[English common name]Ibandronate

[Chinese common name]Ibandronate injection

[English name]

[Chinese other name]

[Indications] BONIVA is suitable for treatment and preventionOsteoporosis in postmenopausal women.

[Usage and Dosage] The recommended dose of BONIVA for the treatment and prevention of postmenopausal osteoporosis is a 2.5 mg film-coated tablet once a day.

[Storage] Store BONIVA at 77 °F (25 °C) or room temperature between 59 °C and 86 °F (15 °C and 30 °C).

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Gaucher disease

Imiglucerase

【Product name】Cerezyme

[English common name]Imiglucerase

[Chinese common name]Imiglucerase

[English name]Cerezyme

[Chinese other name]Brain enzyme

[indications]Gaucher diseaseSymptom improvement (anemia,Thrombocytopenia, hepatosplenomegaly and skeletal symptoms).

【Dosage】As an immunoglucanase (genetic recombination), 60 units/kg body weight is infused every other week for 1 to 2 hours, or an appropriate dose is administered at an infusion rate of no more than 1 unit/kg/min.
For dosing, 1 vial was dissolved in 10.2 mL of water for injection and 10.0 mL was collected per vial. The desired amount of chemical solution is diluted with physiological saline to a final volume of 100-200 ml.
Incidentally, it should be increased or decreased depending on the degree of symptoms.
Further, after a period of administration, the therapeutic effect is judged, and when a sustained improvement state is observed, the maintenance dose can be reduced from the initial amount. The treatment effect can be carefully observed and the body weight can be further reduced at intervals of 3 to 6 months.

[Storage]Store at 2-8 °C in the dark.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Chronic myeloid leukemia , scleroderma

Imatinib

【Product name】Imatinib

[English common name]GLEEVEC

[Chinese common name]Imatinib

[English name]Imatinib intermediates, imatinib

[Chinese other name]Imatinib intermediate, imatinib

[indications]
Imatinib mesylate capsule: for treatmentChronic myeloid leukemia(CML) chronic phase, accelerated phase, or chronic phase after failure of alpha-interferon therapy; malignancy that cannot be surgically removed or metastasizedGastrointestinal stromal tumor (GIST)patient.
Imatinib mesylate tablets: for the treatment of chronic chromosome patients with chronic myeloid leukemia (CML) in Philadelphia, in the blast phase, accelerated phase, or chronic phase after failure of alpha-interferon therapy.
Adult patients for the treatment of malignant gastrointestinal stromal tumors (GIST) that cannot be removed and/or metastasized.

【Dosage】
Imatinib mesylate capsule: starting dose: for patients with blast crisis and accelerated phase of chronic myeloid leukemia, the recommended dose of imatinib mesylate is 600 mg/day; for chronic patients who have failed interferon therapy, and For patients with malignant gastrointestinal stromal tumors (GIST) who cannot be surgically removed or metastasized, the recommended dose is 400 mg/day, which is taken once a day. It is advisable to take the medicine at mealtime and drink a large glass of water. It should be taken continuously.
If the blood picture permits, there is no serious adverse drug reaction, the dose can be considered to increase from 400mg / day to 600mg / day, or from 600mg / day to 800mg / day (400mg, divided into 2 times) in the following cases: disease progression, treatment A satisfactory hematologic response was not obtained after at least 3 months, and the hematologic response that had been obtained disappeared again.
The dose must be adjusted in the following cases: if a serious non-hematologic adverse reaction (such as severe water retention) occurs during the treatment, the drug should be discontinued until the adverse reaction disappears, and then the dose is adjusted according to the severity of the adverse reaction.
Dose adjustment in severe liver toxicity: If the bilirubin rises more than 3 times the upper limit of the normal range or the transaminase rises more than 5 times the upper limit of the normal range, the drug should be discontinued until the above indicators fall to 1.5 or 2.5 times the upper limit of the normal range. the following.
Adjustment of dose during neutropenia or thrombocytopenia: accelerated or blast phase: if severe neutrophils and thrombocytopenia occur (neutrophils <0.5×109/L and/or platelets<10×109/L The recommended dose is reduced to 400 mg / day. If the blood cells continue to decrease for 2 weeks, further reduce the dose to 300 mg / day, if the blood cells continue to decrease for 4 weeks, it is advisable to stop the drug until neutrophils ≥ (greater than or equal to ) 1.0 × 109 / L and platelets ≥ (greater than or equal to) 20 × 109 / L. When used again, the dose is 300 mg / day.
Patients with chronic phase after failure of α-interferon therapy: neutrophils <1.0×109/L and/or platelets <50×109/L should be discontinued, only in granulocyte ≥ (greater than or equal to) 1.5 When x109/L and platelet ≥ (greater than or equal to) 75×109/L, the dosage is 400 mg/day. If the neutrophils or platelets are reduced to the above values, the dosage will be restored. Reduced to 300 mg / day.
Children and adolescents: There are no clinical data on the safety and efficacy of imatinib mesylate in patients under 18 years of age.
Dosage in patients with liver failure: The plasma concentration of imatinib mesylate can be increased in patients with liver damage, so these patients should be cautious when using this drug. There is no liver damage in patients with liver damage. Nie's clinical data, no suggestion for dose adjustment.
Renal failure and dose in elderly patients: creatinine clearance is known to decrease with age, and age has no significant effect on the pharmacokinetics of imatinib mesylate, as it has not been performed in patients with impaired renal function. Clinical trials, so it is not possible to propose a dose adjustment.
Imatinib mesylate tablets: starting dose: The initial treatment should be performed by a physician with experience in treating chronic myelogenous leukemia or GIST.
The product should be taken orally, and it is advisable to take the medicine while eating and drink a large glass of water. Usually adults once a day. Children and adolescents take it once or twice a day (morning and evening).
Patients (children) who cannot swallow tablets can disperse the tablets in water or apple juice. It is recommended that pregnant and lactating women avoid contact with skin or eyes when inhaling capsules, or inhalation (see pregnant and lactating women), and wash hands immediately after touching open capsules.
- therapeutic dose of CML patients
adult
The recommended dose for patients in the chronic phase is 400 mg/day, and for the blast phase and accelerated phase, it is 600 mg/day.
As long as it is effective, it should be taken continuously.
If the blood picture permits, there is no serious adverse drug reaction, the dose can be considered to increase from 400 mg / day to 600 mg / day, or from 600 mg / day to 800 mg / day (400 mg, orally, 2 times) Taking): The disease has not been able to obtain a satisfactory hematologic response after at least 3 months of treatment, and the hematological response has disappeared.
Children and adolescents over 3 years old
So far, children have limited experience in medication. According to the adult dose, the recommended daily dose is: chronic phase 260mg / m2 (maximum dose: 400mg), accelerated phase and blast phase 340mg / m2 (maximum dose: 600mg), the daily recommended dose for children, the calculated dose is generally Should be close to or around 100mg, the dose for children under 12 should generally be as close as possible or around 50mg. There is no experience in treating children under 3 years of age.
- therapeutic dose of GIST patients
For patients with malignant GIST who cannot be removed and/or metastasized, the recommended dose for this product is 400 mg/day.
A satisfactory response was not obtained after treatment. If there were no adverse drug reactions, the dose could be considered to increase from 400 mg/day to 600 mg/day. Treatment time:
For patients with GIST, the product should be treated continuously unless the condition progresses.

[Storage]
Imatinib mesylate capsule: should be kept below 30 °C.
Imatinib mesylate tablets should be kept below 30 °C.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.
Dermal T-cell lymphoma

Vorino

【Product name】Zolinza

[English common name]Vorinostat

[Chinese common name]Vorino

[English name]

[Chinese other name]

[indications]Dermal T-cell lymphoma

[Usage and Dosage] Adult: Oral once a day, 400 mg each time after meals. In addition, it is also necessary to apply according to the patient's condition.

[Storage] Store at 20-25 ° C (68-77 ° F), and allow 15-30 ° C (59-86 ° F).

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

Drug Library

Chronic myeloid leukemia , scleroderma