Mycophenolate mofetil

【Product name】Cellcept

[English common name]Mycophenolate mofetil

[Chinese common name]Mycophenolate mofetil

[English name]

[Chinese other name]

[indications]
Mycophenolate mofetil for injection: This product is used as a preventive medication for organ rejection in patients receiving allogeneic kidney, heart or liver transplantation.
Mycophenolate capsules: prevention of rejection in the same kidney transplant patients and treatment of refractory rejection, can be applied simultaneously with cyclosporine and adrenocortical hormone.
Mycophenolate mofetil dry suspension: for the prevention of organ rejection in patients receiving allogeneic kidney or liver transplantation, mycophenolate mofetil should be combined with cyclosporin A or tacrolimus and corticosteroids Apply at the same time.
Mycophenolate tablets: autoimmune diseases such as pemphigus, bullous pemphigoid, systemic lupus erythematosus (SLE), psoriasis, and the like.
The mycophenolate dispersible tablet: the preventive rejection dose should be taken within 72 hours of transplantation. The recommended dose for kidney transplant patients is 1 gram twice a day (2 grams a day). For daily use, the mycophenolate dispersible tablet 2 g / day is safer than oral g / 3 g / day. Dosage for the Treatment of Refractory Rejection In clinical trials, the first and maintenance dose for the treatment of refractory rejection is recommended to be 1.5 g twice daily (3 g/day).

【Dosage】
Use of mycophenolate mofetil for injection: method of use and drug configuration: intravenous use of this product must be prepared with 5% glucose solution, two vials equivalent to 1 gram dose, the recommended concentration is 6 mg / ml, should use two-step dilution method .
1. The first step:
(1) Inject 20 ml of 5% glucose solution into each vial and shake well. Pay attention to aseptic operation.
(2) Gently shake the vial to dissolve the drug (if the room temperature is low, it can be slightly warm).
(3) After dissolution, the solution should be a pale yellow liquid with no impurities or precipitates. Otherwise it should be discarded.
2. The second step:
(1) The solution was further dissolved with 125 ml of a 5% glucose solution, and the final drug concentration was about 6 mg/ml.
(2) Observe whether the solution is transparent and free of impurities, otherwise it should be discarded.
Mycophenolate capsules: The dose to prevent rejection should be taken within 72 hours of transplantation. The recommended dose for kidney transplant patients is 1 gram twice a day (2 grams a day). Daily service for mycophenolate capsules 2 g / day is safer than oral 3 g / day. Dosage for the Treatment of Refractory Rejection In clinical trials, the first and maintenance dose for the treatment of refractory rejection is recommended to be 1.5 grams twice daily (3 g/day). Special doses should be stopped or reduced if neutropenia (absolute neutrophil count <1.3×103/μl) occurs. Severe renal dysfunction: For patients with severe chronic renal impairment (glomerular filtration rate <25 ml / min / 1.73 m2), avoid more than 1 gram, twice a day (except immediately after transplantation) .
Mycophenolate mofetil dry suspension:
1. The dose to prevent renal transplant rejection. The first dose of this product should be taken orally within 72 hours after transplantation. For kidney transplant patients, it is recommended to take 1 gram each time, twice a day (daily dose is 2 grams). Although 1.5 grams per day, twice a day (3 grams per day) was used in clinical trials and was safe and effective, it did not have an advantage in effect. Patients who received 2 grams of this product per day were better than the 3 grams of patients in terms of overall safety. This product should be applied at the same time as standard doses of cyclosporine and corticosteroids.
2. The dose of treatment for refractory renal transplant rejection. In clinical practice, the therapeutic and maintenance dose for refractory rejection is 1.5 grams each time, twice a day (daily dose is 3 grams). Therefore, a dose of 3 grams per day is recommended for clinical use.
Mycophenolate tablets: The dose of preventive rejection should be started orally within 72 hours of transplantation. The recommended dose for kidney transplant patients is 1 gram each time, twice a day (2 grams a day). Oral morphine mycophenolate tablets 2 g / day is better than oral 3 g / day overall safety. Dosage for the Treatment of Refractory Rejection In clinical trials, the first and maintenance doses for the treatment of refractory rejection are recommended to be 1.5 grams each time, twice a day (3 grams a day).
The mycophenolate dispersible tablet: the preventive rejection dose should be taken within 72 hours of transplantation. The recommended dose for kidney transplant patients is 1 gram twice a day (2 grams a day). For daily use, the mycophenolate dispersible tablet 2 g / day is safer than oral g / 3 g / day. Dosage for the Treatment of Refractory Rejection In clinical trials, the first and maintenance dose for the treatment of refractory rejection is recommended to be 1.5 g twice daily (3 g/day).

[Storage]
Mycophenolate mofetil for injection: sealed and stored.
Mycophenolate capsules: This product should be stored at 15-30 ° C, to avoid moisture, can not be taken after the expiration date indicated on the package. Drugs should be kept out of reach of children.
A dry suspension of mycophenolate mofetil: sealed, kept in a cool place.
Mycophenolate tablets: This product should be stored at 15-30 ° C in the dark. Do not take it after the expiration date indicated on the package. Keep the medicine out of reach of children.
Mycophenolate dispersible tablets: sealed and stored.

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