Introduction
Spermato cell tumor(seminoma) originated from the testis primordial germ cells, the most common tumor of the testis, mostly after middle age, often unilateral, slightly more on the right side than the left side. The incidence of cryptorchidism is several times higher than that of normal testis. The tumor is low in malignancy. From the naked eye, the testicles are swollen, sometimes up to 10 times the normal volume, and in a few cases the testes are normal. Tumors vary in size from small to a few millimeters, and larger to more than ten centimeters, usually 3 to 5 cm in diameter.
abstract
The tumor is highly sensitive to radiation therapy. Lymphatic metastasis is more common, and hematogenous metastasis occurs less frequently. Spermatoblastoma accounts for about 60% of testicular tumors, and the peak incidence is 30 to 50 years old, which is rare in children. In 85% of patients, the testicles were significantly enlarged, the local invasion of the tumor was low, and the tumors generally had obvious boundaries. The development of seminoma is slow, generally first transferred to the retroperitoneal lymph nodes, and extensive hematogenous dissemination can occur in the later stage. When diagnosed, clinical cases account for 60% to 80%.
Disease overview
There are 3 subtypes of seminoma: 1 typical seminoma, about 80%, slow growth, good prognosis; 2 undifferentiated seminoma, about 10%, high degree of malignancy, prognosis ratio Typical seminoma is poor; 3 spermatocyte seminoma, about 10%, more common in patients over 40 years old.
Semena cell tumors occur mostly after middle age, often unilateral, slightly more on the right side than on the left side. The incidence of cryptorchidism is several times higher than that of normal testis. The tumor is low in malignancy. In 85% of patients, the testicles were significantly enlarged, the local invasion of the tumor was low, and the tumors generally had obvious boundaries. The development of seminoma is slow, generally first transferred to the retroperitoneal lymph nodes, and extensive hematogenous dissemination can occur in the later stage. When diagnosed, clinical cases account for 60% to 80%.
Pathologically, germ cell tumors accounted for 90-95%, and non-germ cell tumors accounted for 5-10%. Germ cell tumors can be classified into seminoma, non-seminoma such as embryonal carcinoma, teratoma, teratocarcinoma, chorionic epithelial cell carcinoma, and yolk sac tumor according to the differentiation of cells. Most testicular tumors can have early lymphatic metastasis, reaching the lymph nodes adjacent to the renal pedicle at the earliest, and there is blood transfer in the early stage of chorionic epithelial cancer.
A typical seminoma has the characteristics of a single morphological structure of the tumor cells and lymphocytic infiltration in the interstitial. The tumor cells are diffusely distributed or have a cord-like structure. The morphology of the cells is the same. It is similar to the spermatogonial cells in the normal seminiferous tubules. The tumor cells are large, round or polygonal, with clear boundaries, transparent cytoplasm, large nuclei, central, and nuclear membrane. And the chromatin is thicker, there are 1 or 2 eosinophils, and mitosis is rare.
Pathological analysis
Spermato cell tumor
The seminoma has a single morphological structure and lymphocytic infiltration in the interstitial. The two interstitial mesenchyme are fine fibrous tissue or dense collagen fibers, accounting for 60% of testicular tumors, and the peak incidence is 30-50 years old. Rare in children. Since the testicular white membrane is relatively tough and not destroyed by the tumor, the original outline of the testicle is usually preserved. The tissue of the facet is yellowish or grayish yellow, solid and uniform, such as fish, and irregular necrotic areas are often seen. The interstitial is a fine fibrous tissue or dense collagen fibers, in which there are many inseparable lymphocytes infiltrated, and sometimes there are lymphoid follicles.
From the naked eye, the testicles are swollen, sometimes up to 10 times the normal volume, and in a few cases the testes are normal. Tumors vary in size from small to a few millimeters, and larger to more than ten centimeters, usually 3 to 5 cm in diameter. Since the testicular white membrane is relatively tough and not destroyed by the tumor, the original outline of the testicle is usually preserved. The tumor cells are diffusely distributed or have a cord-like structure. The morphology of the cells is the same. It is similar to the spermatogonial cells in the normal seminiferous tubules. The tumor cells are large, round or polygonal, with clear boundaries, transparent cytoplasm, large nuclei, central, and nuclear membrane. And the chromatin is thicker, there are 1 or 2 eosinophils, and mitosis is rare.
There are 3 subtypes of seminoma: typical seminoma, about 80%, slow growth, good prognosis; undifferentiated seminoma, about 10%, high degree of morbidity, prognosis than typical Poor progenitor cells; spermatogonial seminoma, accounting for about 10%, more common in patients over 40 years of age.
The tissue of the facet is yellowish or grayish yellow, solid and uniform, such as fish, and irregular necrotic areas are often seen. Microscopically, a typical seminoma. How many lymphocytes infiltrate, and sometimes there are lymphoid follicles. The tumor is highly sensitive to radiation therapy. Lymphatic metastasis is more common, and hematogenous metastasis occurs less frequently.
Cause of disease
Spermatoblastoma can be divided into two types: germ cell tumor and non-germ cell tumor. The former occurs in the reproductive epithelium of the curved fine tube, accounting for about 95%; the latter is from the interstitial cells, accounting for about 5%. More common in the 25-44 years old, with regional differences in ethnicity. The cause of seminoma is unclear and may be related to race, heredity, cryptorchidism, chemical carcinogens, injury, endocrine, etc.
Insufficiency of spermatogonial cells: this is the main cause of this disease. Testicular local temperature rise, blood supply disorders, endocrine dysfunction, testicular atrophy, spermatogenic disorders, prone to malignant transformation. In addition, congenital testicular dysfunction, incomplete decline, is also prone to malignant transformation.
Genetics: In recent years, some people with semen cell tumors have a family history of oncology in about 16% of their close relatives.
Testicular female syndrome: According to the World Health Organization (WHO) 1977 classification of seminoma, the testicular female syndrome is also prone to seminoma.
Trauma: It is considered that trauma is not the direct cause of tumorigenesis, but after testicular trauma, local small hematoma formation or blood circulation disorder, tissue degeneration and atrophy, etc., on the basis of this tumor.
Infection: A variety of viral diseases, such as measles, smallpox, viral mumps and bacterial inflammation, can be complicated by orchitis, resulting in testicular cell deformation and spermatogonia.
Hormones: Clinical and animal experiments suggest that endocrine is related to the genesis of testicular tumors. For example, testicular tumors occur mostly in young adults with strong gonads, or in active endocrine; animal experiments such as long-term administration of estrogen to rats can induce seminoma. Chinese medicine believes that: emotional dysfunction, or angry liver injury, liver qi stagnation, spleen spleen, spleen and dampness, leaving the liver, long-term formation of hard lumps. "Zheng deficiency and evil spirits" is its pathological mechanism.
Dialectical analysis
Spermatoblastoma is a low-grade malignant tumor that develops slowly and the testicles are painlessly enlarged. About 75% of seminomas are confined to the testis at the time of diagnosis, 10% to 15% of patients have both metastatic and regional retroperitoneal lymph node lesions, and 5% to 10% of patients have advanced regional lymph nodes. Or an organ transfer. The preferred treatment for most patients after groin orchiectomy is radiation therapy. The irradiation field included the para-aortic and ipsilateral axillary lymphatic drainage area, and the dose was DT20～30Gy. The time to start radiotherapy should be performed as soon as possible after orchiectomy, usually 10 days after surgery, and should not exceed 1 month. Long-term complications of radiation therapy include infertility, gastric ulcer, and second primary tumor caused by radiation.
Testicular seminoma goes through five long stages in oncogene, precancerous lesions, subclinical, carcinoma in situ, metastatic cancer, etc. It takes about 2-20 years, and the enveloping circle of colloidal fibers is getting weaker and weaker. The number of capillaries is from nothing, from small to many, and finally becomes a capillary group. In other words, cancer is a sudden increase in capillaries, a lack of hard proteins, and a chronic disease.
Chinese medicine knows that testicular seminoma, called renal cystoma, is a blood-heat syndrome, just like milkstone; therefore, the treatment is the same. Surgical resection began in the 1950s, but the survival rate of patients with testicular seminoma is still very low.
Testicular seminoma tumors are less than three centimeters, no metastasis, can be surgically removed, but because of the destruction of the cancer encirclement, it is easy to provoke metastasis; after resection, no radiotherapy and chemotherapy.
In patients with testicular seminoma, regardless of marital status, whether unilateral or bilateral testicular disease, the doctor should inform the possible birth hazard, and remind patients to consider refrigerated sperm before surgery or before radiotherapy. Surgery may cause immune infertility. Radiotherapy may cause damage to the gonads, accessory gonads and insemination pipelines, seriously affecting the testicular spermatogenesis process, killing sperm, and severe patients may cause azoospermia. Refrigerating sperm can solve the worries of fertility problems.
Diffusion method
Testicular seminoma spreads in four ways:
1. In the testicular tissue, cancer cells spread in the testis on the side.
2, testicular cancer cells into the lymphatic system growth, called lymphatic metastasis, the chest is next to the bronchi, the hilar, mediastinal lymph nodes; chest outside the clavicle, armpit and upper abdomen lymph nodes.
3, testicular cancer cells into the blood system growth, called blood transfer, lung transfer is most common, followed by growth in the liver, bones, etc.
4, iatrogenic transfer, is the Western medicine surgery, cancer cells are planted in the abdominal cavity or in the incision, more common.
Infertility
Spermatoblastoma is the most common testicular tumor in adults, accounting for 60% to 8% of testicular germ cell tumors. The accepted treatment for seminoma is the in vitro radiotherapy of retroperitoneal lymph nodes after orchiectomy, with a 5-year survival rate approaching 95%. Spermatogonia cells are extremely sensitive to radiation, but may cause infertility after irradiation. The treatment of infertility caused by radiotherapy of seminoma cells, especially azoospermia, has few clinical reports. Traditional Chinese medicine method is used to diagnose and treat azoospermia caused by postoperative radiotherapy in patients with right spermatogonia. The spouse is successfully conceived by intracytoplasmic perfusion (ICSI).
Adult men have a total testicular weight of about 30g, and can produce 10 million sperm per gram of testicular tissue per day, producing about 200-300 million sperm per day. The sperm is shaped like a scorpion and has a length of about 60 μm. It is divided into four parts: the head, the neck, the body and the tail. The head is large, the neck and the body are equal to the length of the head, and the tail is 10 times the length of the head. The head of the sperm has acrosome and nucleus. The acrosome covers 2/3 of the nucleus. There are many enzymes in the head. These are called acrosome enzymes. They are substances that break through the "shell" of the egg and the transparent band during fertilization. There are chromosomes in the nucleus of the head, which are substances that carry the genetics of the father. The neck and body are mainly cytoplasmic components, which are the parts that maintain sperm life and provide energy for sperm activity. The tail is very long and consists of some proteins. When these protein fibers shrink, the sperm tail can be swung in all directions, and sperm movement occurs. Generally, the forward movement speed of sperm is about 50 to 60 μm per second. Sperm with strong fertility can climb up to a height of about 5cm.
Sperm production requires a suitable temperature, and the temperature inside the scrotum is about 2 °C lower than the temperature in the abdominal cavity, which is suitable for sperm production. During embryonic development, for some reason, the testicle does not fall into the scrotum and stay in the abdominal cavity or in the groin, called cryptorchidism, the seminiferous tubules can not develop normally, and no sperm is produced. If the testicles of mature animals are warmed or experimental cryptorchidism is performed, the spermatogenic cells may be degraded and atrophied.
The newly released sperm is released into the luminal lumen of the curve, and it does not have the ability to exercise itself. Instead, it is transported into the epididymis by the contraction of the peripheral muscle-like cells of the small tube and the movement of the lumen fluid. In the epididymis, the sperm further matures and gains exercise capacity. A small amount of sperm can be stored in the epididymis, and a large amount of sperm is stored in the inferior tube and its ampulla. In sexual activity, sperm is transported to the urethra by peristalsis of the vas deferens. Sperm is mixed with the secretions of the epididymis, seminal vesicles, prostate and urethral glands to form semen, which is injected outside the body during orgasm. Normal men shoot about 3-6ml of semen each time. Each milliliter of semen contains about 20 to 400 million sperm, less than 20 million sperm, and it is not easy to fertilize the egg.
Clinical stage
The pathological type of seminoma is associated with prognosis, and the extent of tumor spread and the extent of metastasis also affect prognosis. Therefore, the clinician should not only understand the pathological type of the tumor, but also develop a corresponding treatment plan according to the difference of the extent of the disease. Therefore, it is practical to determine the stage of disease in each patient. The most commonly used staging methods today are:
Stage I: The tumor is confined to the testis and epididymis, but has not broken through the capsule or invaded the spermatic cord, and has no lymph node metastasis.
Stage II: Physical examination, X-ray examination confirmed that there has been metastasis, can spread to the spermatic cord, scrotum, and inguinal lymph nodes, but did not exceed the retroperitoneal lymphatic area. Those with clinical metastasis of metastatic lymph nodes were stage IIa, and those with clinical examination of abdominal and abdominal lymph nodes were stage IIb.
Stage III: There have been lymph node metastasis or distant metastasis above the diaphragm. Some researchers have also classified distant distant people into stage IV.
Clinical features
Posterior lateral position of seminoma
Seminoma is the most common mediastinal malignant blastoma, accounting for 2% to 4% of mediastinal tumors, 13% of mediastinal malignancies, and 50% of mediastinal malignant germ cell tumors. Almost all young men, the peak age of onset is 20-40 years old, located in the anterior mediastinum, 80% have symptoms.
20%-30% of patients are asymptomatic, symptomatic patients with symptoms of chest pain, cough, difficulty breathing, hemoptysis, etc., can have lethargy, weight loss. Superior vena cava obstruction syndrome occurs in 10% to 20% of patients. These clinical symptoms are often associated with oppression and invasion of the mediastinal structure of the tumor. A portion of the seminoma is grown in the trachea and locally spreads to the adjacent mediastinum and lungs. Generally, the mediastinal seminoma is metastasized by lymphatic metastasis, and hematogenous metastasis can also occur. Bone and lung are the most frequently metastatic sites.
Chest radiographs often have large anterior mediastinal tumors, and sometimes tumors can be found growing along the trachea. Most of the CTs are large masses with uniform density, and 50% of the chest can be seen to metastasize or expand beyond the anterior mediastinum and cannot be operated. CT and MRI help determine the extent of the tumor and the violation of the mediastinal structure. The first visit removal rate was less than 25%.
Blood alpha-FP, β-hCG levels should be measured in all young men with pre-mediastinal tumors. There is almost no increase in AFP and hCG in pure seminoma, and hCG is elevated in 7%-10%, but often does not exceed 100 ng/ml, and AFP does not increase.
CA125 may also be a biological marker. Chromosomal analysis of tumor tissue reveals characteristic isometric arm chromosomes on chromosome 12, which is useful for identifying germ cell tumors and other types of tumors. [2]
Inspection Method
Abnormal immune response: The immune response that does not occur in normal tissues and cells is expressed in the corresponding tumor tissues, and all are abnormal immune responses. If CK occurs in a variety of mesenchymal tumors, desmin can be expressed in hemangioendothelioma and cancer.
Epithelioid sarcoma Keratin, Vimentin, CEA, NSE, S-100 and α1-AT can be positive; Ewing sarcoma Keratin, Vimentin positive for a long time, S-100, NSE, neurofilament (NF) and Leu-7 can be Positive; malignant fibrous histiocytoma except for α1-AT and α-ACT positive, Vimentin, Desmin and NF can be positive. All of these indicate that the above tumors are characterized by multi-directional differentiation. [3]
Diagnostic identification
Electron microscopic observation of seminoma is important for the differential diagnosis of soft tissue malignant tumors, especially for some diagnostic ultrastructures, which have a decisive effect on the diagnosis. For example, clear cell sarcoma can be diagnosed as soft tissue melanoma by containing melanin bodies or pre-melanin bodies in electron microscopic tumor cells.
Especially in the differential diagnosis of spindle cell type, round, oval cell type tumors, specific ultrastructural features, see the various tumors described below. A large number of immunohistochemical studies have shown that various markers are useful in determining the diagnosis, but are not completely specific. For example, a group of muscle markers, originally thought to be specific for skeletal muscle, smooth muscle type tumors, but both desmin and actin can react with myofibroblastic and fibrous tissue cell tumors.
It has now been found that HMB45 is also available in non-melanocyte tumors. Therefore, a correct diagnosis can not be judged only based on the results of positive expression of immunohistochemical antibodies. It is necessary to integrate the patient's condition, tumor location, tumor cell morphology and growth type with marker staining results for synthesis. Analyze, judge, and finally determine the diagnosis.
Abnormal immune response: The immune response that does not occur in normal tissues and cells is expressed in the corresponding tumor tissues, and all are abnormal immune responses. If CK occurs in a variety of mesenchymal tumors, desmin can be expressed in hemangioendothelioma and cancer.
Epithelioid sarcoma Keratin, Vimentin, CEA, NSE, S-100 and α1-AT can be positive; Ewing sarcoma Keratin, Vimentin positive for a long time, S-100, NSE, neurofilament (NF) and Leu-7 can be Positive; malignant fibrous histiocytoma except for α1-AT and α-ACT positive, Vimentin, Desmin and NF can be positive. All of these indicate that the above tumors are characterized by multi-directional differentiation.
Chinese treatment
Party 1: Radix Rehmanniae, Hawthorn, Alisma, Ligustrum lucidum, Eclipta prostrata, Scorpion, and Cuscuta L., licorice 58, yam, paeonol, and alfalfa 12g:
Side 2: ginseng, Atractylodes, Astragalus, Radix Rehmanniae, Radix Paeoniae Alba, Angelica, Ligustrum lucidum, Scorpion l0g, licorice 5g, Astragalus 15g.
System usage: a yin deficiency fire card,
User 1: It is a qi and blood deficiency syndrome,
Use party 2. Can also add or subtract with the disease. 1 dose per day, Shuijianbi. Thirty patients in the control group were treated with a linear accelerator (or 60Co).
Efficacy: The treatment of abdominal malignant tumors with the above drugs (species including seminoma, malignant lymphoma and gastric cancer, pancreatic cancer, abdominal metastatic cancer), the two groups were excellent, 11 cases, good, 14, 10 cases; poor 5, 15 cases. The 3-year survival rate was 68% and 32%, respectively (P<0.01). The life and psychological quality, physical condition score treatment group were better than the control group 1: Radix Rehmanniae, Hawthorn, Alisma, Ligustrum lucidum, Eclipta prostrata, Scorpion, Dodder, each l0g, licorice 58, yam, paeonol, medlar Each 12g;
Side 2: ginseng, Atractylodes, Astragalus, Radix Rehmanniae, Radix Paeoniae Alba, Angelica, Ligustrum lucidum, Gardenia 10g, Licorice 5g, Astragalus 15g.
Usage: It is a yin deficiency fire card.
Western medicine treatment
Treatment of clinical stage I testicular seminoma
Any testicular tumor should be preceded by high testicular removal, and then the treatment plan should be selected according to the pathological type and clinical stage. Spermatogonia cells are highly radiosensitive, and lower doses can eliminate metastatic lesions without significant radiation damage. Clinical stage I testicular seminoma, after high testicular removal, should be used for preventive irradiation of ipsilateral axillary lymph nodes and retroperitoneal lymph nodes. Linear accelerator high energy ray, 60Co and kilovolt X-ray can be used as external sources. However, high doses of preventive radiation are not necessary.
Treatment of clinical stage II testicular seminoma
In the clinical stage IIa, the retroperitoneal metastatic lymph nodes are small, and the irradiation is the same as the clinical stage I; the clinical stage IIb metastatic lymph nodes are larger, and the irradiation field should be designed according to the size of the metastases to fully include the lymph nodes, and the abdominal cavity is widely metastasized. The clinical phase II radiotherapy dose segmentation is the same as the clinical phase I. After the mid-plane dose of 25Gy, the stage IIa shrinkage field enhances the irradiated lymph node 10Gy, the total mid-plane dose should reach 35Gy/4~5 weeks; the IIb phase enhances the irradiation 15Gy, total The dose reached 40 Gy. Clinical stage II testicular seminoma, whether it is necessary to carry out mediastinal and left supraclavicular area to prevent radiation, is still controversial.
Treatment of clinical stage III and IV testicular seminoma
Clinical stage II, III and IV testicular seminoma should be treated with radiotherapy and chemotherapy. The treatment of stage III cases is the same as stage II, but the dose of metastatic lymph nodes in the mediastinum and left supraclavicular region should reach 35~40Gy. /5~6 weeks. Clinical stage IV cases have distant metastasis before treatment. Chemotherapy should be the main method, supplemented by radiotherapy to control local lesions, and no preventive radiation. Treatment with chemotherapy radiotherapy-chemotherapy, that is, "sandwich" technology is reasonable, that is, first three courses of chemotherapy, then 35 ~ 40Gy / 5 ~ 6 weeks, and then 3 to 4 courses of chemotherapy.
Testicular seminoma is sensitive to a variety of anti-tumor drugs, China's first N-formyl sarcoma treatment of testicular seminoma, taking 150 ~ 200mg every night before going to bed, 6 ~ 8g for a course of treatment, the total effective rate 91.3%, of which 2/3 were completely relieved. Recently, the combination of PVB or VAB-6 and PVP16 has been used, and the cure rate of stage III cases is 90%.
Radiotherapy
Postoperative radiotherapy can reduce the recurrence rate of tumor sites and para-aortic and pelvic lymph nodes, because surgical treatment can remove the touched and seen masses and enlarged lymph nodes, but can not completely remove the microscopic lesions around the tumor and Subclinical lesions, so radiotherapy and surgery can be long and short. By surgically removing the main tumor mass and using medium-dose radiation therapy to eliminate residual microscopic lesions and subclinical lesions, both local control rate and radiotherapy complications can be reduced. For patients with stage II C and III combined with chemotherapy under the premise of radiotherapy, spermatogonia with distant metastasis can shrink or even disappear, relieve symptoms, and prolong the life of some patients. Pay attention to important aspects such as positioning and positioning. At the same time, it also emphasizes that in the specific case of para-aortic lymph node metastasis and pelvic lymph node metastasis, this key issue should be treated actively and steadily. Therefore, it is advocated that there is no distant transfer or There is a distant metastasis that should be treated aggressively.
Family therapy
Patients with testicular seminoma have several special symptoms to note:
1 In patients with testicular seminoma, the earliest symptom is male breast development. This phenomenon is often considered to be a lack of androgen and is ignored by doctors. The doctor gives the patient some testosterone instead of checking the patient's testicles. If the light illuminates the bilateral scrotum, it will be found that the size of the two testicles is significantly different, and the toughness is completely different.
2 testicular swelling, or abdominal mass is the cause of the patient's visit. At this time, you should drink flavored [appetizing soup]; drink broth, especially beef tendon soup to eat collagen.
3 Due to testicular swelling, the affected side has a heavy feeling, and there is traction discomfort in the groin. If internal bleeding occurs, it will cause severe pain. Want to eat Yunnan Baiyao. Drink flavored [appetizing soup].
4 patients with testicular seminoma should avoid sexual intercourse and prevent testicular congestion and worsen.
5 China has been undergoing surgical resection since the 1950s. Some patients have wound healing after surgery. To drink beef tendon soup, usually heal in 7 days.
6 Some patients have cancer cell rupture after radiotherapy and chemotherapy. This kind of rupture is extremely difficult to heal. The same is true of other cancers. Only a large dose of beef tendon soup to eat collagen, promote the healing of ulcers.
7 testicular seminoma has little ascites. If there is a peritoneal effusion, do not pump water, and do not require intracavitary chemotherapy. I used a variety of drugs for intracavitary injections and killed many people. Want to eat Yunnan Baiyao.
8 metastatic masses will compress nearby organs. Retroperitoneal lymph node metastasis can cause back pain and sciatica; mediastinal lymph node metastasis can cause superior vena cava syndrome, swelling of the face and upper extremities; pelvic lymph node metastasis can cause inferior vena cava and decidual pool compression syndrome, lower extremity Elephant skin swelling; lung metastasis, can cause difficulty in breathing, tachycardia; rectal metastasis, can cause constipation; should be 50-100 ml of 20% mannitol injection after breakfast. If you squeeze the bladder, there will be difficulty in urinating, and even cause hydronephrosis, resulting in kidney damage, the patient will have systemic edema; 5 grams of Guizhi should be added in the flavored "appetizing soup", 10 grams of white peony.
Diet therapy
Meat food
Dietary therapy for epididymal tuberculosis: 煨 sparrow: 3 sparrows, remove hair and remove dirty, add 10 grams of fennel, 3 grams of pepper, 6 grams of Amomum villosum, 6 grams of cinnamon, wet paper wrapped, cooked, fasting Send clothes with wine. Applicable to yang deficiency and phlegm-type epididymal tuberculosis Huangqi Ejiao Dihuang porridge: 30 grams of Astragalus, 30 grams of Ejiao, 100 grams of glutinous rice or glutinous rice, porridge; porridge adult rehmannia juice 150 ml, boiled for a while, take. Applicable to yin deficiency and sputum type epididymal tuberculosis
Diet and precautions:
Improve physical fitness. Physical weakness, excessive fatigue, lack of sleep, and intense and lasting mental work are all factors. Should actively engage in physical exercise, enhance physical fitness, and pay attention to rest, prevent overwork, and avoid heavy physical labor.
Food supplement: mainly dog meat, lamb, sparrow, walnut, bullwhip, sheep kidney, etc.; in addition, zinc-containing foods such as mutton, beef, chicken liver, eggs, peanuts, pork, chicken, etc., containing arginine foods such as yam, Ginkgo, frozen tofu, squid, sea cucumber, cuttlefish, octopus, etc., all contribute to the improvement of physical fitness.
Usually diet: men should eat more sea cucumber. Sea cucumber is rich in nutrients, and it has strong energy and is often eaten. It is rare or lacking for men's sperm, and it is often effective. You can take 100 grams of sea cucumber soup, add seasoning, and take the sea into the soup. You can also use yam to stew the lily. Usage: Take fresh yam peeled 250 grams, 25 grams of lily, add water to stew until the lily is rotten, add 10 grams of rock sugar, 3 times cool food. This side is especially suitable for men who are rare in sperm and who are deceitful. At the same time, you can often take the outer kidneys of sheep, dogs, cattle and other animals, including their penis and testicles, braised or boiled.
prevent disease
People who eat more dairy products are also at higher risk of developing the disease. Especially those who eat a lot of cheese, the risk of testicular cancer is 87% higher than the average person. Therefore, quitting smoking and adjusting bad eating habits are the key to prevention.
Tobacco contains carcinogenic substances such as arsenic, and smoking can cause changes in sex hormones. Therefore, scientists have long suspected that smoking may be one of the risk factors for disease. Studies have shown that smoking does increase the risk of developing testicular cancer.
1 early treatment of seizure, to avoid testicular trauma and excessive sexual intercourse, has a certain significance in the prevention of seminoma.
2 treatment of cryptorchidism should be 4-6 years old, no more than 7-11 years old; can be treated with endocrine therapy for 2 weeks, testicular fixation is not effective.
Abnormal immune response: The immune response that does not occur in normal tissues and cells is expressed in the corresponding tumor tissues, and all are abnormal immune responses. If CK occurs in a variety of mesenchymal tumors, desmin can be expressed in hemangioendothelioma and cancer.
Epithelioid sarcoma Keratin, Vimentin, CEA, NSE, S-100 and α1-AT can be positive; Ewing sarcoma Keratin, Vimentin positive for a long time, S-100, NSE, neurofilament (NF) and Leu-7 can be Positive; malignant fibrous histiocytoma except for α1-AT and α-ACT positive, Vimentin, Desmin and NF can be positive. All of these indicate that the above tumors are characterized by multi-directional differentiation.
Abnormal immune response: The immune response that does not occur in normal tissues and cells is expressed in the corresponding tumor tissues, and all are abnormal immune responses. If CK occurs in a variety of mesenchymal tumors, desmin can be expressed in hemangioendothelioma and cancer.
Epithelioid sarcoma Keratin, Vimentin, CEA, NSE, S-100 and α1-AT can be positive; Ewing sarcoma Keratin, Vimentin positive for a long time, S-100, NSE, neurofilament (NF) and Leu-7 can be Positive; malignant fibrous histiocytoma except for α1-AT and α-ACT positive, Vimentin, Desmin and NF can be positive. All of these indicate that the above tumors are characterized by multi-directional differentiation.
Abnormal immune response: The immune response that does not occur in normal tissues and cells is expressed in the corresponding tumor tissues, and all are abnormal immune responses. If CK occurs in a variety of mesenchymal tumors, desmin can be expressed in hemangioendothelioma and cancer.
Epithelioid sarcoma Keratin, Vimentin, CEA, NSE, S-100 and α1-AT can be positive; Ewing sarcoma Keratin, Vimentin positive for a long time, S-100, NSE, neurofilament (NF) and Leu-7 can be Positive; malignant fibrous histiocytoma except for α1-AT and α-ACT positive, Vimentin, Desmin and NF can be positive. All of these indicate that the above tumors are characterized by multi-directional differentiation.
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