Introduction
Parathyroid carcinomaExtremely rare, the incidence is about 0.5% to 4.0% of primary hyperparathyroidism.
Clinical manifestation
Parathyroid carcinoma occurs in 40 to 50 years old, with a little more men. The main clinical manifestations of parathyroid carcinoma are hyperparathyroidism and secondary organ damage secondary to hypercalcemia, osteoporosis, bone cystic changes and pathological fractures, urinary calculi, neck masses, involving laryngeal regurgitation There may be hoarseness in the nerves, and the incidence of acute pancreatitis is about 15%. The above clinical manifestations appear to be easily misdiagnosed as treatment of bone and joint diseases or urinary calculi, which may delay the timing of treatment.
Inspection diagnosis
Clinically, patients with recurrent urinary calculi and bone and joint pain, muscle weakness, and minor trauma can cause pathological fractures. X-ray examination also shows extensive decalcification, loose and cystic changes in the bone should be considered thyroid Paragonadoma. Increased blood calcium and alkaline phosphatase, and decreased blood phosphorus, have important value in the diagnosis of this disease. In the corresponding part of the parathyroid gland, the tumor is detected. B-ultrasound or CT examination of the enlarged parathyroid gland can be diagnosed as parathyroid tumor, resulting in pathological diagnosis of parathyroid carcinoma.
treatment method
Once the diagnosis is established, surgery should be performed as soon as possible. During the operation, frozen sections should be used to identify benign and malignant. Parathyroid carcinoma should be treated with cancer, ipsilateral thyroid and thymus. If lymph node metastasis should be performed in the same side of the neck lymph node dissection, postoperative interventional chemotherapy can be better.
The treatment of parathyroid cancer is crucial for the first operation. For the first operation, if the cancer is completely removed, about 50% of the patients can be cured, and the recurrence of postoperative recurrence is rare. The main purpose of conservative treatment is to reduce and control. Hypercalcemia, parathyroid cancer is not sensitive to chemotherapy and radiotherapy. Compared with other cancers, the disease has a good prognosis. The 10-year survival rate is about 13%, and the average survival time is 7.6 years. The death is rarely caused by the primary cancer itself. Most patients die from the secondary side. Hemorrhoids and uncontrolled hypercalcemia, as well as renal failure caused by it, nervous system changes and arrhythmias.
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