Monoclonal antibodies

【Product name】IILARIS, ADCETRIS, Muromonab

[English common name]Monoclonal antibody

[Chinese common name]Monoclonal antibodies

[English name]

[Chinese other name]

[indications]
Iodine [131I] tumor cell nuclear human mouse chimeric monoclonal antibody injection: for the late stage of radiotherapy and chemotherapy can not control or relapseLung cancerRadioimmunotherapy.
Recombinant anti-CD25 humanized monoclonal antibody injection: This product is suitable for preventing the occurrence of acute rejection after renal transplantation, and can be combined with an immunosuppressive regimen containing a calmodulin inhibitor and corticosteroids.

【Dosage】
Iodine [131I] tumor cell nuclear human mouse chimeric monoclonal antibody injection:
1. Medication method:
(1) Systemic administration: This product can be directly bolused, or intravenously established with saline to make a bolus or instillation.
(2) Topical administration: The drug is injected into the tumor by pulmonary puncture under imaging guidance (CT, fluoroscopy or DSA).
2. Dosage: Two times per course of treatment, with an interval of 2-4 weeks. The specific dosage is:
(1) Systemic intravenous injection: The dose is 29.6 MBq (0.8 mCi)/kg.
(2) Topical administration: Each dose was 18.5-37.0 MBq (0.5-1 mCi)/cm3 of tumor, and the maximum dose was 1850 MBq (50 mCi).
Recombinant anti-CD25 humanized monoclonal antibody injection: the recommended dose is 1mg/kg, diluted to 50mL of 0.9% sodium chloride injection before use, and then intravenously infused, 15 minutes after the end. The first dose should be administered within 24 hours prior to transplantation, and then administered once every 14 days, twice for a course of treatment. This product can not be directly injected, but should be diluted with 50% of 0.9% sodium chloride injection before intravenous administration. Do not violently oscillate when mixing the solution and gently flip it to prevent foaming. Since this product does not contain any preservatives or bacteriostatic agents, it must be carefully stored to ensure the solution is sterile. This product is a colorless liquid contained in a disposable bottle. Any unused parts after opening should be discarded. Do not dilute and infuse with other drugs in the same solution.

[Storage]
Iodine [131I] tumor cell nuclear human mouse chimeric monoclonal antibody injection: sealed, shading, and stored in a dry place.
Recombinant anti-CD25 humanized monoclonal antibody injection: stored and transported at 2-8 ° C in the dark. Do not freeze or shake vigorously. After dilution, the drug solution can be stored at 2-8 ° C for 24 hours and at room temperature for 4 hours.

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