Eculizumab

【Product name】SOLIRIS, Eculizumab

[English common name]Eculizumab

[Chinese common name]Eculizumab

[English name]Dimer (9CI)

[Chinese other name]

[Indications] Soliris is a drug used to treat adults and children:Paroxysmal nocturnal hemoglobinuria(PNH);Atypical hemolytic uremic syndrome(aHUS). Soliris can also be used to suffer fromMyasthenia gravisAdults (another rare disease in which the immune system attacks and damages muscle cells that cause muscle weakness), other drugs do not work, and specific antibodies in the body are called AChR antibodies.

【Dosage】Paroxysmal nocturnal hemoglobinuria (PNH)
The dosing regimen for PNH treatment consists of a 4-week initial phase and then a maintenance phase:
-Initialphase: 600 mg mg of Soliris as an intravenous infusion for 25-45 minutes, once a week at week 4
- Maintenance phase: 900 mg of Soliris is administered as an intravenous infusion for 5 to 45 minutes per week for 5 minutes, followed by intravenous infusion of 900 milligrams of Soliris, which is every 25 ± 45 minutes at 25-45 minutes (see " Attribute application/effect ").
Atypical hemolytic uremic syndrome (AHU)The dose regimen for aHUS for adult treatment (≥18 years) consists of a 4-week induction period followed by a maintenance period:
Intravenous infusion of 900 mg milligrams of Soliris once a week, 25-45 minutes before 4:-Induktionsphase administration week
-Erhaltungsphase: 1200 mg of Soliris is administered as an intravenous infusion over 5 to 45 minutes for 5 weeks, followed by 1200 mg of Soliris for intravenous infusions for every 14 ± 2 days of administration over 25 to 45 minutes (see "Properties" /effect")

[Storage]Precautions: Store in the refrigerator (+ 2 ° C to + 8 ° C).Do not freeze.Store in original packaging to protect against light.The original packaged drug can be stored outside the refrigerator for a period of up to 3 days. After this, the original packaged drug can be stored in the refrigerator again. Shelf life: 30 months. This medicine contains no preservatives. The drug should be used immediately after dilution. However, the chemical and physical stability used has been demonstrated for 24 hours at 2 °C - 8 °C.

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