Everolimus

【Product name】Certican, AFINITOR, Afinitor Disperz

[English common name]Everolimus

[Chinese common name]Everolimus

[English name]

[Chinese other name]

[Indications] for late treatment after failure with sunitinib or sorafenibRenal cell carcinomaTreatment of the patient.

【Dosage】
1.10mg once or twice a day with or without food.
2. Treatment discontinuation and / or dose reduction to 5 mg once a day may require treatment of adverse drug reactions.
3. For patients with Child-Pugh Category B liver injury, reduce the dose to 5 mg once a day.
4. If a moderate CYP3A4 or P-glycoprotein (PgP) inhibitor is required, reduce the AFINITOR dose to 2.5 mg once daily; if tolerance is to be increased to 5 mg once daily.
5. If a strong inducer of CYP3A4 is required, increase the dose of AFINITOR by 5 mg to a maximum of 20 mg once a day.

[Storage] sealed and stored.

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