Aiku group monoclonal antibody

【Product name】Soliris

[English common name]Eculizumab

[Chinese common name]Aiku group monoclonal antibody

[English name]

[Chinese other name]Eculizumab

[Indications] Soliris is a complement inhibitor suitable for:
(1) T treatmentParoxysmal nocturnal hemoglobinuria(PNH) patients reduce hemolysis.
(2) treatment of atypical hemolytic uremic syndrome (aHUS) patients with inhibition of complement-mediated thrombotic microangiopathy.

[Usage and Dosage] The recommended dose is 2 mg / kg intravenously, the minimum range is 3.5 to 4.5 hours, based on the infusion volume, once a week. It is recommended to use antihistamines or no antipyretics for pre-treatment 30 to 60 minutes before the start of the infusion.
In the case where the solution and container permit, the particulate matter and discoloration of the parenteral drug product should be visually inspected prior to administration.
The patient is administered a dilute solution using a low protein binding infusion set fitted with a low protein binding 0.2 micron (μm) in-line filter.
Note: The safety and efficacy of Vimizim has not been determined in pediatric patients of less than 5 years.
For patients weighing less than 25 kg, the first infusion rate should be 3 mL per minute for 15 minutes, and if it is tolerated, increase to 6 mL per hour for the next 15 minutes. If you tolerate this ratio, the speed can be increased every 15 minutes, 6 ml per hour, no more than 36 ml each time.
hour. The total infusion should be completed in at least 3.5 hours.
For patients weighing 25 kg or more, the first infusion rate should be 6 ml per hour for 15 minutes. If it is tolerated, the infusion rate can be increased to 12 mL per hour for the next 15 minutes.
If this rate is tolerable, the rate can be increased in increments of 12 milliliters per hour for every 15 minutes instead of over 72 milliliters per hour. The total amount of infusion should be delivered for at least 4.5 hours.

[Storage] Store in the refrigerator (2 ° C – 8 ° C). Do not freeze. Store in original packaging to protect against light.
The Soliris vial in the original package can be removed from the freezer only once for up to 3 days. At the end of this period, the product can be returned to the refrigerator.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

Description

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product manual

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Product information

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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    [Storage] sealed and protected from light

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.