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  Chronic stable angina , Vasospasm angina pectoris

  Amlodipine atorvastatin

  【Product name】Caduet

  [English common name]Amlodipine besylate/atorvastatin calcium

  [Chinese common name]Amlodipine besylate / atorvastatin

  [English name]ATORVASTATIN CA, pd134298-38a

  [Chinese other name]Atorvastatin, levamlodipine besylate

  [indications]Up to one ® (amlodipine and atorvastatin) is indicated for patients requiring a combination of amlodipine and atorvastatin.
  Amlodipine
  1, high blood pressure
  Amlodipine is indicated for the treatment of hypertension. Can be used alone or in combination with other antihypertensive drugs.
  2, coronary heart disease (CAD)
  Chronic stable angina
  Amlodipine is indicated for the symptomatic treatment of chronic stable angina. Can be used alone or in combination with other anti-angina drugs.
  Vasospasm angina (Prinzmetal's or variant angina)
  Amlodipine is indicated for the treatment of confirmed or suspected vasospasm angina. It can be used alone or in combination with other anti-angina drugs.
  Angiographically confirmed coronary heart disease
  Patients with recent coronary angiography confirmed coronary artery disease, but with an ejection fraction of ≥40% and no heart failure, amlodipine can reduce the risk of hospitalization for angina and reduce the risk of coronary revascularization.
  Atorvastatin
  1, hypercholesterolemia
  Patients with primary hypercholesterolemia, includingFamilial hypercholesterolemiaPatients with (heterozygous) or mixed hyperlipidemia (equivalent to Types IIa and IIb of the Fredrickson classification) may be treated with elevated or low total cholesterol if they are not satisfied with dietary and other non-pharmacological treatments. Increased density lipoprotein cholesterol, elevated apolipoprotein B, and elevated triglycerides.
  inHomozygous familial hypercholesterolemiaIn patients, atorvastatin calcium can be combined with other lipid-lowering therapies (such as LDL plasma dialysis) or used alone (when there is no other treatment) to lower total cholesterol and low-density lipoprotein cholesterol.
  2, coronary heart disease:
  Patients with coronary heart disease or coronary heart disease (such as: diabetes, symptomatic atherosclerotic disease, etc.) with hypercholesterolemia or mixed dyslipidemia, this product is suitable for: reducing the risk of nonfatal myocardial infarction, Reduce the risk of fatal and non-fatal strokes, reduce the risk of revascularization, reduce the risk of hospitalization for congestive heart failure, and reduce the risk of angina.

  [Usage and Dosage] When using this product to treat hypertension or angina pectoris with hyperlipidemia, the individualization of the therapeutic dose must be considered, and the patient's treatment effect and tolerance for each component should be adjusted accordingly.
  Amlodipine (hypertension or angina)
  Adult: Usually the initial dose of this product for the treatment of hypertension is 5mg, once a day, the maximum dose is 10mg, once a day. In patients with small, weak, elderly, or with hepatic insufficiency, the initial dose is 2.5 mg once daily; this dose can also be used in combination with other antihypertensive drugs.
  The dose adjustment should be based on the patient's individual response. It should generally be 7-14 days later so that the doctor can assess the patient's response to each dose. Dose adjustments can also be made quickly, if clinically required, in the case of close monitoring of the patient.
  The recommended dose for the treatment of chronic stability or vasospasm angina is 5-10 mg. Once daily, elderly patients with hepatic insufficiency are advised to use lower doses. The effective dose for most people is 10 mg once daily. Dosage and side effects can be found in the [Adverse Reactions] section.
  The recommended dose for the treatment of coronary heart disease is 5-10 mg once daily. In clinical studies, most patients require a dose of 10 mg once daily.
  Children: For children aged 6-17 years, the recommended oral dose for the treatment of hypertension is 2.5 mg to 5 mg once daily. There are no studies of more than 5 mg in children.
  Atorvastatin (hyperlipidemia)
  A commonly used starting dose is 10 mg once daily. The dose adjustment interval should be 4 weeks or longer. The maximum dose of this product is 80mg once a day. The daily dose of atorvastatin can be taken at any time during the day and is not affected by the meal.
  For low-risk patients with cardiovascular events, the treatment goal is LDL-C<4.14mmol/L (or <160mg/dL) and total cholesterol <6.22mmol/L (or <240mg/dL). The target of treatment for intermediate-risk patients is LDL- C<3.37mmol/L (or <130mg/dL) and total cholesterol <5.18mmol/L (or <200mg/dL), the target of treatment for high-risk patients is LDL-C<2.59mmol/L (or <100mg/dL) And total cholesterol <4.142mmol / L (or <160mg / dL), the target of treatment for very high-risk patients is LDL-C <2.07mmol / L (or <80mg / dL) and total cholesterol <3.11mmol / L (or <120mg / dL).
  From the Chinese Journal of Cardiovascular Diseases, Vol. 35, No. 5, pp. 390-413, 2007, Guidelines for Prevention and Treatment of Diabetes in Adults in China.
  Treatment of primary hypercholesterolemia and mixed hyperlipidemia
  Most patients take atorvastatin calcium 10 mg once daily and their blood lipid levels can be controlled. The curative effect was observed within 2 weeks of treatment, and the maximum effect was seen within 4 weeks of treatment. Long-term treatment can maintain efficacy.
  Treatment of heterozygous familial hypercholesterolemia
  The initial dose of the patient was 10 mg/day. The dose should be adjusted stepwise to 40 mg/day at intervals of 4 weeks, following the individualized principle of dose. If the satisfactory effect is still not achieved, the dose can be adjusted to a maximum dose of 80 mg / day or 40 mg once daily with a bile acid sequestrant.
  Treatment of homozygous familial hypercholesterolemia
  In a charitable study involving 64 patients, 46 patients had confirmed LDL receptor information. The LDL-C of these 46 patients decreased by an average of 21%. The dose of this product can be increased to 80mg / day.
  For patients with homozygous familial hypercholesterolemia, the recommended dose of this product is 10 -80mg / day. Atorvastatin should be used as an adjunct to other lipid-lowering treatments (such as LDL plasma dialysis), or when these conditions are not available, this product can be used alone.
  Dose of patients with renal insufficiency
  Kidney disease does not affect the plasma concentration of atorvastatin or its effect on lowering LDL-C. Therefore, in patients with renal insufficiency, there is no need to adjust the dose.
  As many as one
  The use of this product is equivalent to the separate use of its two components and can be replaced with each other. The patient may be given the same dose of the drug, or to increase anti-angina, lowering blood pressure or lowering the fat, or add amlodipine or atorvastatin or both at the same time.
  This product can be used in patients who have used one of atorvastatin or amlodipine and need to add another drug. Since one indication is the initial treatment and the other indication is the maintenance treatment, the dose of the product should be selected according to the maintenance amount of the ingredient being used and the recommended starting amount of the added single ingredient.
  This product can be used for the initial treatment of patients with hypertension or angina pectoris with hyperlipidemia. The recommended starting dose should be appropriately combined according to the recommended dose for each monotherapy. The maximum dose of amlodipine in this product can reach 10mg, once a day, the maximum dose of atorvastatin can reach 80mg, once a day.
  For details on the usage and dosage of atorvastatin and amlodipine, refer to the above section.

  [Storage] shading, confined storage.

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