Adenosine deaminase (ADA)
【Product name】Strimvelis, Adenosine Deaminase Antibody
[English common name]Adenosine Deaminase
[Chinese common name]Adenosine deaminase (ADA)
[English name]ADA
[Chinese other name]Adenine deaminase
[indications]Strimvelis is available for the treatment of severe combined immunodeficiency due to adenosine deaminase deficiency (ADA), a relevant stem cell donor who does not have a suitable human leukocyte antigen (HLA) match.
【Dosage】
Strimvelis must be performed by a professional transplant center, with ADA-SCID patient treatment and management experience and with a physician using autologous CD34 + ex vivo gene therapy products. Strimvelis should only be performed after consultation with patients and/or family members. Patients are expected to enter the post-treatment registry and will be followed for long-term follow-up.
CD34+ stem cells containing at least 1 million CD34+ cells per kilogram are required for use. This should be harvested from the patient at least 3 weeks prior to treatment with Strimvelis. If the product is manufactured after treatment with Strimvelis, failure occurs during transplantation or long-term bone marrow dysplasia, the stem cells are collected for use as salvage therapy.
Patients must be able to donate enough CD34+ cells to provide the minimum of 4 million purified CD34+ cells/kg required to make Strimvelis.
Strimvelis is for self-use only. Prior to infusion, the patient's identity must be confirmed to match the basic unique patient information on the Strimvelis infusion bag and/or container.
[Storage] shelf life of 6 hours, must be stored inAt 15-30 ° C.
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