Cloweidipine butyrate

【Product name】Cleviprex

[English common name]Clevidipine

[Chinese common name]Cloweidipine butyrate

[English name]

[Chinese other name]

[Indications] For the treatment of hypertension that is not suitable for oral or oral administration, it can also be used to treat acute blood pressure after surgery.

[Usage and Dosage] Monitoring
When injecting this product, the patient's blood pressure and heart rate should be continuously monitored until the patient's signs are stable. For patients who continue to infuse this product for a long time and have not switched to other antihypertensive drugs, at least 8 hours of rebound hypertensive hypertension monitoring should be performed after the end of the infusion. Such patients may require follow-up adjustments in blood pressure control.
Recommended dose
This product is an intravenous drug preparation, the dosage should be gradually adjusted during use to achieve the desired antihypertensive effect. The specific dose depends on the expected antihypertensive effect and the patient's response.
Starting dose:
The initial dose of intravenous infusion of this product is l ~ 2mg / hour.
Dose adjustment:
The dose can be doubled at intervals of a short time (90 seconds). When approaching the target antihypertensive effect, the increased dose should be less than double, and the time interval for adjusting the dose should be extended to 5 to 10 minutes. In general, for every 1-2 mg/hour increase in dose, the systolic blood pressure can be further reduced by 2 to 4 mmHg.
Maintenance dose:
Most patients achieve a desired therapeutic response by measuring 4 to 6 mg/hour. For patients with severe hypertension, it may be necessary to increase the dose to 32 mg / hour, but the clinical experience of this dose is limited.
Maximum dose:
The maximum dose for most patients does not exceed 16 mg/hour. Short-term medication experience with a dose of 32 mg/hour is limited. Due to the limitation of lipid intake, it is recommended that the infusion of this product within 24 hours does not exceed 1000m1 or an average of 21mg/hr. In clinical studies, 55 hypertensive patients received more than 500 ml of this product within 24 hours. Almost no infusion of this product (all doses) more than 72 hours of medication experience.
Switch to other antihypertensive drugs:
When determining the appropriate oral antihypertensive drug, you can stop using this product or gradually reduce the dose of this product. In the initial stage of oral antihypertensive drugs, the delay time of oral drug onset should be considered. Blood pressure should continue to be monitored until the desired effect is achieved.

[Storage] The 50 mL expiration date is the ML filling size (2-8oC) at the time of refrigerated storage for 24 months. 100mL can be obtained for 36 months of shelf life, and the filling size when stored in cold storage. Both configurations can store up to 2 months of control room temperature as "in use" storage.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

Description

name

Attention: The internal data of table “681” is corrupted!

product

Attention: The internal data of table “682” is corrupted!

product manual

Click to view clodipine butyrate English product description

Click to view the product description of clevidipine butyrate

Product information