Botulinum toxin

【Product name】XEOMIN

[English common name]incobotulinumtoxinA

[Chinese common name]Botulinum toxin

[English name]BTX, Botulinum Toxin

[Chinese other name]Net good, angel bot

[Indications] Eyelids, hemifacial spasms and related disorders of dystonia.

[Usage and Dosage] The recommended dose of this product should not be interchanged with the dose of other Clostridium botulinum toxin preparations. This product must be used by a physician with appropriate qualifications and experience in treatment, and with appropriate equipment. The optimal effective dose and the optimal number of injection sites per muscle have not yet been established, so individual treatment regimens should be developed by the physician and the optimal dose should be determined by titration. Ailigen will assist in the training of this product injection technology. The recommended dose range for each injection site is 0.05-0.1 ml (eyelid, hemifacial spasm). See the following dilution table. Injection of this product with a sterile, 27-30/0.40-0.30mm needle does not necessarily require EMG monitoring. The recommended initial injection dose for the lateral part of the medial and lateral parts of the upper orbital iliac muscle of the upper eyelid iliac muscle is 1.25-2.5 U. If the eyebrows, the lateral aspect of the orbicularis and the upper facial area affect visual acuity, the injection site should also be increased at the corresponding site. Avoiding injections close to the upper eyelid side can reduce complications of drooping eyelids. Avoid the injection of the inside of the lower eyelid to reduce the spread of the oblique muscle, which can reduce the complications of double vision. The lower icon shows the injection reference site: it takes effect within three days after the general injection and reaches a peak in 1-2 weeks. Each treatment lasts for approximately 3 months and can be repeated as needed. When repeating treatment, if the initial therapeutic dose is considered insufficient, the injected dose can be increased or even doubled. However, if an injection site dose exceeds 5.0 U, there will be no better effect. The initial therapeutic dose per eye should not exceed 25U. In general, treatment frequencies greater than once every 3 months are not beneficial to the patient. When treating eyelids, the total dose per 12 weeks should not exceed 100U. Hemifacial spasm and VII pairs of patients with abnormal brain function, treatment of patients with unilateral orbital, and other affected facial muscles can be injected as needed. If the first treatment fails, ie one month after the injection, there is no significant clinical improvement compared to before treatment, the following measures should be taken: • Clinical validation, including specialists performing an EMG examination of the blockade of injected muscle; • Analysis failure Causes such as: improper selection of injected muscles, insufficient injection dose, lack of injection technique, occurrence of fixed muscle contracture, antagonism of muscle weakness, neutralization of toxin antibody formation, etc.; • Re-evaluation of treatment with Clostridium botulinum toxin type A; • If the first treatment is not effective, the following measures can be taken for the second treatment:
(1) Analyze the cause of the first treatment failure and adjust the dose;
(2) Injection under EMG monitoring;
(3) There is a three-month interval between the two treatments. If the reinjection treatment fails or is not effective, consider replacing the treatment. How to use, handle and dispose of this product: It is recommended to carry out the dilution operation and the preparation of the syringe on the paper towel with plastic liner to prevent the liquid from splashing. The product was diluted with sterile, preservative-free saline (0.9% sodium chloride for injection). Draw the appropriate amount of diluent with a syringe (see the dilution table below). Since the product will be denatured by the vibration of bubbles or similar forces, the diluent should be gently pushed into the bottle. If there is no vacuum suction in the bottle, the bottle should be discarded. After preparation, this product should be a clear liquid with no color to slightly yellow and no impurities. Before using the preparation solution, visually check the clarity and impurities. The preparation solution should be stored in the refrigerator (2 ° C - 8 ° C) for up to 4 hours. This product can only be used in a single use, and the remaining solution should be discarded. For safety reasons, unused vials should be filled with a small amount of water and then autoclaved; all used vials, syringes, and spilled liquids should be autoclaved or 0.5% hypochlorous acid. The salt solution inactivated the residue of the product for 5 minutes.

[Storage] Store at 2oC~8oC in cold storage or below -5oC. After preparation: Store at 2oC~8oC in cold storage and use within 4 hours. Container: A 10 ml capacity type I colorless glass bottle with a rubber stopper and sealed with aluminum foil.

[Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.