整合分析鉴定肝癌预后、诊断、免疫浸润及治疗药物相关枢纽基因

肝癌是全球最常见的癌症之一,也是癌症死亡的原因。目的是通过综合分析阐明有益于肝癌诊断、预后和靶向治疗的新型枢纽基因。 GSE84402、GSE101685 和 GSE112791 从基因表达综合 (GEO) 中过滤。差异表达基因 (DEGs) 使用 GEO2R 进行鉴定。在 DAVID 中分析了 DEG 的 GO 和 KEGG 途径。DEG 的 PPI 和 TF 网络是通过使用 STRING、TRANSFAC 和 Harmonizome 构建的。基于癌症基因组图谱(TCGA)在 UALCAN 中分析了枢纽基因与肝癌预后之间的关系。通过ROC评估hub基因的诊断价值。在TIMER中分析hub基因与肿瘤浸润淋巴细胞之间的关系。在 HPA 中验证了 hub 基因的蛋白质水平。在 DGIdb 中鉴定了中枢基因和药物之间的相互作用。 总共有 108 个上调和 60 个下调的 DEG 富集在 148 个 GO 术语和 20 个 KEGG Read more...

Introduction to liver disease

Introduction Liver disease is any liver dysfunction that causes disease. The liver is responsible for many of the key functions within the body, and if it becomes sick or injured, the loss of these functions can cause serious damage to the body. Liver disease is also known as liver disease. The cause of the cells is inflamed, such as hepatitis. Bile flow may be blocked, such as cholestasis). Cholesterol or triglycerides can accumulate, such as steatosis). Blood flow to the liver may be affected. Liver tissue may be destroyed by chemicals and minerals, or by abnormal cells such as cancer cells. Symptoms are dull: unlike sun-tanned skin, the face is dull and dull; in addition, severe dark circles are early symptoms of chronic liver disease, most of which are chronic hepatitis B. Yellowing of the skin: People who have never had hepatitis, early symptoms of liver disease patients after chills, fever, nausea, vomiting, liver pain, extreme fatigue, sudden appearance of yellow eyes and skin, it indicates that acute jaundice hepatitis; If jaundice occurs in patients with chronic hepatitis, it indicates that the condition is aggravated. Liver palm: It is very different from the color of the palm of an ordinary person. The color of the palm of an ordinary person is ruddy, and the palm of a patient with liver disease is white and bloodless. Spider mites: There is a red dot in the middle, and there is a bloody filament around it. It is similar to the symptoms after mosquito bites. When the center of the sputum is pressed with one end of the sputum, the sputum disappears, and it will appear after release. The early symptoms of this liver disease patient can be Identification of other vasospasm. According to reports, males have spider mites on the surface, and 85% of them have different degrees of liver tissue lesions, of which about 30% are cirrhosis. Diagnosis Many liver function tests (LFT) can be used to test the normal function of the liver. These tests typically present enzymes in the liver, tissues, metabolites or the most abundant blood in the product. Serum protein, serum albumin, serum globulin, alanine aminotransferase, aspartate aminotransferase, prothrombin time, partial thromboplastin time. Imaging tests, such as transient elastography, ultrasound and magnetic resonance imaging, can be used to examine liver tissue and bile ducts. Liver biopsy can be performed to examine liver tissue to distinguish various conditions; tests such as elastography may reduce the need for biopsy in some cases. There are no relevant information on the complications. Therapeutic antiviral drugs can be used to treat infections such as hepatitis B. Other conditions can be controlled by slowing the progression of the disease, for example: Treatment of autoimmune hepatitis by using steroid-based drugs. A certain amount of blood is regularly taken from the vein (venous incision) of iron overloaded hemochromatosis. Wilson's disease is a condition in which copper accumulates in the body and can be treated with copper-bound drugs that can be excreted from the urine. Cholestatic liver disease (because of cystic fibrosis leading to bile flow) may give a drug called ursodeoxycholic acid (URSO, also known as UDCA).

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