疫苗可改善新诊断的脑癌患者的生存结局

据疫苗制造商 AIVITA Biomedical Inc. 称,与新诊断的胶质母细胞瘤患者的标准治疗相比,使用个性化癌症疫苗 AV-GBM-1 进行治疗可显着改善生存结果。 在大约 6 个月内接种了 8 剂疫苗的 57 名患者中,AV-GBM-1 的中位无进展生存期(治疗期间和治疗后的时间)为 10.4 个月,而 AV-GBM-1 为 6.9 个月在另一项研究中观察到放疗加化疗替莫唑胺;这转化为比针对该人群的既定护理标准提高了约 50%。 在分析时,患者已完成治疗,并在入组后 10.1 个月至 27.6 个月之间进行了随访。中位总生存期(从诊断或开始治疗到患者仍然活着的时间长度)尚未达到,将在最后一位患者进行至少 15 个月的随访后进行评估。 此外,发现该疫苗总体耐受性良好,在 28 名患者中报告了 54 种严重副作用;然而,这些毒性均未确定与治疗相关。 该研究的主要作者,加州大学欧文分校医学主任丹妮拉博塔博士说:“这一里程碑是对抗(胶质母细胞瘤)的令人鼓舞的第一步,胶质母细胞瘤是一种对患者及其家人具有毁灭性影响的疾病。”综合脑肿瘤计划,在新闻稿中。 该制造商正在美国对胶质母细胞瘤和黑色素瘤患者进行两项疫苗研究。 “AV-GBM-1 在新诊断(胶质母细胞瘤)患者中显着改善(无进展生存)的潜力超过目前的护理标准是非常令人鼓舞的,”AIVITA 的首席医疗官 Robert O. Dillman 博士在报告中说。释放。

Brain tumor introduction

Introduction: Intracranial tumors, also known as brain tumors, are still unknown. The tumors originate from the brain, meninges, pituitary gland, cranial nerves, cerebrovascular and embryonic residual tissues, and are called primary intracranial tumors. A malignant tumor organized by other organs of the body is transferred to the intracranial, called a secondary intracranial tumor. Causes: Intracranial tumors, also known as brain tumors, are still unknown. Symptoms: The following four aspects of pathophysiological processes are caused by intracranial tumors causing increased intracranial pressure and gradually worsening: tumor volume exceeds intracranial pressure regulation compensatory capacity; reactive cerebral edema around the tumor; cerebrospinal fluid circulation obstruction; vein The backflow is blocked. Headache, vomiting, and optic nerve head edema are the "three main symptoms" of increased intracranial pressure and the main clinical symptoms of intracranial tumors. 1. Headache: About 80% of patients are the most common early symptoms, but they are not the main basis for diagnosis. Anyone who can aggravate the increase of intracranial pressure can aggravate headache. 2, vomiting: has nothing to do with diet, more common in the morning. Vomiting is often accompanied by severe headaches, sometimes with jetting, but non-ejection vomiting is not uncommon. 3, optic nerve head edema: early no visual impairment, with the prolongation of the time, the development of the disease, the visual field of mind shrinking, the late optic nerve secondary atrophy, visual acuity decreased rapidly, which is also associated with optic neuritis caused by pseudo optic nerve nipple The main points of edema differentiation. Optic papilledema is an important objective basis in the "three main symptoms." Diagnosis: Intracranial tumors often require intracranial inflammation such as brain arachnoiditis, purulent and tuberculous meningitis, tuberculoma, brain abscess, chronic subdural hematoma, intracerebral hematoma, hypertensive encephalopathy and cerebral infarction, intracranial Parasitic diseases, granuloma, mycosis, optic nerve papillitis and posterior optic neuritis. Complications: Local symptoms are also known as localized symptoms. The local symptoms are different due to the location of the glioma. Clinically, according to its performance, combined with other judgments of the location of the tumor. The most important symptom of the lesion, that is, the direct compression of the tumor to stimulate or destroy the brain tissue or cranial nerve results, has a positioning value. However, it is most diagnostic in the early stage of the disease. In the advanced stage, due to the indirect effects of brain tissue and cranial nerves in other parts, such as oppression, edema and involvement, some adjacent symptoms and distant symptoms of the tumor appear. The former is caused by compression of the brain or cranial nerve near the tumor. For example, cerebellar tumors have symptoms of pons and medulla oblongata; sacral tumors have III and IV cranial nerve disorders; lateral fissures have hemiplegia. The occurrence of the above symptoms is related to tumor compression, brain tissue displacement or cerebral blood circulation disorders. The distant symptom is a dysfunction of the cranial nerve in the distant part of the tumor, such as a posterior fossa tumor, which may cause visual, auditory hallucinations or epilepsy due to hydrocephalus affecting the amount, sputum and parietal lobe. Another example is when the intracranial pressure is increased, due to the enlargement of the third ventricle, bilateral hemianopia and saddle enlargement may occur. Treatment: First, Western medicine treatment 1, symptomatic treatment mainly for increased intracranial pressure, such as the application of dehydration drugs to reduce intracranial pressure; for epilepsy authors to apply anti-epileptic drugs. Because the tumor is located in the vital part, it is impossible to perform surgical resection, and when the drug treatment effect is not good, palliative surgery such as cerebrospinal fluid shunt, diaphragmatic decompression, occipital decompression or decompressive craniectomy can be performed. 2, the cause of treatment: 1 is mainly surgical resection of the tumor, the principle of surgical resection is: all benign tumors stress the total resection to achieve the effect of cure; all malignant tumors or benign tumors located in important functional areas should be based on patient conditions and technical conditions Most of them are removed or partially removed to achieve decompression. 2 All malignant tumors or benign tumors that are not completely resected and sensitive to radiation should be treated with radiation after surgery. 3 malignant tumors, especially gliomas and metastases, after surgery, in addition to radiation therapy, can also be treated by chemical drugs through different ways and methods, referred to as chemotherapy. In order to improve the effect of malignant brain tumor after surgery and prolong the survival of patients, radiotherapy, chemotherapy, and immunotherapy are collectively referred to as comprehensive treatment of brain tumors. 3, Chinese medicine treatment can be used as one of the comprehensive treatment measures, suitable for some patients who are not suitable for surgery and radiotherapy, chemotherapy or recurrence after surgery. Second, Chinese medicine treatment methods Chinese medicine treatment of brain tumors is currently mainly used in patients before or after surgery, adjuvant therapy after radiotherapy and chemotherapy or inoperable and radiotherapy and chemotherapy. The traditional Chinese medicine treatment of brain tumors mainly controls the development and metastasis of tumors, reduces the tumor remission and reduces the adverse reactions of radiotherapy and chemotherapy; and achieves the purpose of treatment. Improve the quality of life and prolong life. Traditional Chinese medicine treatment of brain tumors has fewer side effects and can be used for a long time. It has been repeatedly studied through a large number of clinical data: Brucea javanica oil emulsion has great effect on the treatment of brain tumors. Brucea javanica Oral Emulsion is an oil-based oral emulsion made from traditional Chinese medicine with modern high-tech. Its main component is oleic acid, which is an anti-tumor active ingredient. It is a new type of targeted pure Chinese medicine anti-cancer preparation; it is easy to penetrate the blood-brain barrier and has good curative effect on brain tumors and brain metastases; it can inhibit topoisomerase activity and thus inhibit cellular DNA. Synthesis and growth, blocking the proliferation of cancer cells, degeneration and necrosis of cancer cells; and no damage to normal cells. Brucea javanica has been widely used in the treatment of brain tumors. It has a promoting effect on humoral immunity and cellular immunity; and it has killing and inhibiting effects on various cancer cells. Brucea javanica oral emulsion has a good therapeutic effect in the treatment of brain tumors. Clearly validated in clinical cases. Traditional Chinese medicine and traditional Chinese medicine preparations play an important role in the treatment of brain tumors, both before and after surgery, after radiotherapy and chemotherapy; Chinese medicine treatment is the best choice for brain tumors. Drugs for the treatment of brain tumors, such as temozolomide capsules (Tiqing) and semustine capsules (ring nitrosourea) have also been effective in the treatment of brain tumors. Prevention: According to a survey of residents in six cities in China, the prevalence of intracranial tumors is 32/100,000, and a worldwide statistics is 40/100,000. It shows that the incidence of intracranial tumors is not low and it is worthy of attention. In terms of the incidence of systemic tumors, brain tumors ranked fifth (6.31%), only lower than the stomach, uterus, breast, esophageal tumors. In adults, brain tumors account for 2% of the total number of tumors in the body. Childhood brain tumors account for a relatively large proportion of tumors in various parts of the body, accounting for 7% of systemic tumors. Brain tumors can occur at any age and are more common in adults. Infants and young people and those over 60 years old have fewer onsets. There is no significant difference between general onset and gender, but individual tumors are related to gender. The site of tumor occurrence, the number of people on the screen is more than the curtain, the ratio of the incidence of the two is about 3:1. The brain tumors on the screen are mostly located in the frontal lobe and temporal lobe. The under-mens are more common in the cerebellar hemisphere and the crotch, the fourth ventricle, and the cerebellopontine angle.

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