Paroxysmal nocturnal hemoglobinuria

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  • Paroxysmal nocturnal hemoglobinuria

    Eculizumab

    【Product name】SOLIRIS, Eculizumab

    [English common name]Eculizumab

    [Chinese common name]Eculizumab

    [English name]Dimer (9CI)

    [Chinese other name]

    [Indications] Soliris is a drug used to treat adults and children:Paroxysmal nocturnal hemoglobinuria(PNH);Atypical hemolytic uremic syndrome(aHUS). Soliris can also be used to suffer fromMyasthenia gravisAdults (another rare disease in which the immune system attacks and damages muscle cells that cause muscle weakness), other drugs do not work, and specific antibodies in the body are called AChR antibodies.

    【Dosage】Paroxysmal nocturnal hemoglobinuria (PNH)
    The dosing regimen for PNH treatment consists of a 4-week initial phase and then a maintenance phase:
    -Initialphase: 600 mg mg of Soliris as an intravenous infusion for 25-45 minutes, once a week at week 4
    - Maintenance phase: 900 mg of Soliris is administered as an intravenous infusion for 5 to 45 minutes per week for 5 minutes, followed by intravenous infusion of 900 milligrams of Soliris, which is every 25 ± 45 minutes at 25-45 minutes (see " Attribute application/effect ").
    Atypical hemolytic uremic syndrome (AHU)The dose regimen for aHUS for adult treatment (≥18 years) consists of a 4-week induction period followed by a maintenance period:
    Intravenous infusion of 900 mg milligrams of Soliris once a week, 25-45 minutes before 4:-Induktionsphase administration week
    -Erhaltungsphase: 1200 mg of Soliris is administered as an intravenous infusion over 5 to 45 minutes for 5 weeks, followed by 1200 mg of Soliris for intravenous infusions for every 14 ± 2 days of administration over 25 to 45 minutes (see "Properties" /effect")

    [Storage]Precautions: Store in the refrigerator (+ 2 ° C to + 8 ° C).Do not freeze.Store in original packaging to protect against light.The original packaged drug can be stored outside the refrigerator for a period of up to 3 days. After this, the original packaged drug can be stored in the refrigerator again. Shelf life: 30 months. This medicine contains no preservatives. The drug should be used immediately after dilution. However, the chemical and physical stability used has been demonstrated for 24 hours at 2 °C - 8 °C.

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

  • scleroderma , Paroxysmal nocturnal hemoglobinuria

    Dextran

    【Product name】 INJECTAFER, LOW MOLECULAR DEXTRAN D INJECTION, INFED, DEXTRAN

    [English common name]Dextranum

    [Chinese common name]Dextran

    [English name]

    [Chinese other name]

    [indications]
    Low molecular weight dextran amino acid injection: for the treatment of patients with reduced blood volume with protein deficiency
    Compound dextran 40 injection: acute hemorrhage, especially suitable for initial treatment of acute massive hemorrhage; surgical hypovolemic shock due to trauma, burn (hot) and hemorrhage; blood volume reduction during surgery: reduction in extracorporeal perfusion The risk of complications due to extracorporeal circulation.
    Dextran 40 Glucose Injection: This product is suitable for:
    1. Shock is used for shock and toxic shock caused by various causes such as blood loss, trauma and burns.
    2. Prevention of postoperative venous thrombosis for limb replantation and vascular surgery to prevent postoperative thrombosis.
    3. Vascular embolism is used for angina pectoris, cerebral thrombosis, insufficient blood supply to the brain, and thromboangiitis obliterans.
    4. During extracorporeal circulation, replace part of the blood, pre-fill the artificial heart-lung machine, which not only saves blood but also improves circulation.
    Dextran hypromellose eye drops: reduce discomfort such as burning and irritation caused by dry eyes, and protect the eye from irritation. Reduce eye discomfort caused by exposure to sand or sunlight.

    【Dosage】
    Low molecular weight dextran amino acid injection: intravenous drip. 500ml once a day, can be used continuously for 4 to 5 days or as directed by a doctor.
    Compound dextran 40 injection: 500-1000 mL of this product is infused intravenously every adult, and the dosage should be adjusted according to the patient's age, clinical performance and body weight. The dose of the extracorporeal circulation solution is 20 to 30 mL/kg, and the dextran 40 is 2 to 3 g/kg.
    Dextran 40 Glucose Injection:
    1. Intravenous infusion, the dosage depends on the condition, the amount of adult commonly used is 250 ~.00ml, not more than 1000 ~ 1500ml within 24 hours. The amount of the baby is 5 ml/kg, and the amount of the child is 10 ml/kg.
    2. Shock cases: the dosage can be larger, the speed can be faster, the infusion rate is 20-40 ml/min, and the maximum dose can be 20 ml/kg on the first day, and the dehydration must be corrected before use.
    3. Prevention of postoperative thrombosis: 500ml during or after surgery, usually 500ml / day on the first and second day after surgery, intravenous infusion at a rate of 2 to 4 hours, high-risk patients, the course of treatment can be used up to 10 days.
    4. Vascular embolism disease: should be slowly intravenous infusion, generally 250 ~ 500ml each time, daily or every other day, 7 to 10 times for 1 treatment
    Dextran hypromellose eye drops: According to the condition, eye drops, 1-2 drops each time.

    [Storage]
    Low molecular weight dextran amino acid injection: shading, stored below 25 ° C
    Compound dextran 40 injection: shading, confined preservation
    Dextran 40 Glucose Injection: Store below 25 ° C
    Dextran hypromellose eye drops: shading, sealed preservation

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

  • Paroxysmal nocturnal hemoglobinuria

    Prednisone

    【Product name】Pletmol, Orapred, PREDONEMA

    [English common name]Prednisone

    [Chinese common name]Prednisone

    [English name]Deltacortone, Meticorten

    [Chinese other name]Prednisone, dehydrocortisone

    [Indications] This product is mainly used for allergic and autoimmune inflammatory diseases. Suitable for connective tissue disease, systemic lupus erythematosus, severe polymyositis, severe bronchiasthma, dermatomyositis, vasculitis and other allergic diseases,Acute leukemia,Malignant lymphoma. And other conditions suitable for other adrenocortical drugs.

    【Dosage】
    1. Oral usually 5 ~ 10mg (1 ~ 2 tablets), 10 ~ 60mg a day (2 ~ 12 tablets).
    2. For autoimmune diseases such as systemic lupus erythematosus, stomach syndrome, ulcerative colitis, autoimmune hemolytic anemia, 40 to 60 mg per day can be given, and the condition is gradually reduced after the condition is stable.
    3. For allergic diseases such as drug dermatitis, urticaria, bronchial asthma, prednisone can be given 20 to 40 mg per day. After the symptoms are alleviated, the amount is reduced, and the amount is reduced by 5 mg every 1 to 2 days.
    4. To prevent rejection of organ transplants, generally take 100mg daily for 1 to 2 days before surgery, and change to 60mg per day for one week after surgery, and then gradually reduce the amount.

    [Storage] sealed and protected from light

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

  • Paroxysmal nocturnal hemoglobinuria

    Prednisolone

    【Product name】Pred Forte, Omnipred, Pred Mild, Inflamase Forte, AK-Pred, Econopred Plus

    [English common name]Prednisolone

    [Chinese common name]Prednisolone

    [English name]Ocu-Pred Forte

    [Chinese other name]Prednisolone

    [indications]
    Prednisolone acetate eye drops: This product is suitable for short-term treatment of steroid-sensitive eye inflammation (excluding viral, fungal and bacterial pathogen infections).
    Prednisolone acetate injection: This product is mainly used for allergic and autoimmune inflammatory diseases. Now used for active rheumatism,Rheumatoid arthritis, lupus, severe bronchiasthma, nephrotic syndrome, thrombocytopenic purpura,Granulocyte reduction, various adrenal insufficiency, severe dermatitis,Acute leukemiaEtc. Also used for the comprehensive treatment of certain infections.
    Prednisolone acetate tablets: This product is used for allergic and autoimmune inflammatory diseases, collagen diseases. Such as rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, nephrotic syndrome, thrombocytopenic purpura, neutropenia, acute lymphocytic leukemia, various adrenal insufficiency, exfoliative dermatitis, blister Acne neurodermatitis, eczema and so on.

    【Dosage】
    Prednisolone acetate eye drops: drip into the conjunctival sac. 1 to 2 drops at a time, 2 to 4 times a day. 24 to 48 hours from the start of treatment, the dose can be increased to 2 drops per hour as appropriate. Be careful not to stop the drug too early.
    Prednisolone acetate injection: intramuscular or intra-articular injection: 10 ~ 40mg a day, if necessary, can increase the amount.
    Prednisolone acetate tablets: Oral for the treatment of allergic, autoimmune inflammatory diseases.
    1. Adults start 15 ~ 40mg (3-8 tablets) a day (according to the condition), 60mg (12 tablets) or 0.5 ~ 1mg / kg per day can be used when needed, fever patients take 3 times, normal body temperature daily Get up in the morning.
    2. After the condition is stable, gradually reduce the amount, maintain the amount of 5 ~ 10mg (1-2 tablets), depending on the condition.
    3. Children start to use 1mg/kg a day.

    [Storage]
    Prednisolone acetate eye drops: Store at room temperature (15 ~ 25 ° C), do not freeze
    Prednisolone acetate injection: shading, sealed and preserved
    Prednisolone acetate tablets: shading, sealed and preserved

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

  • Paroxysmal nocturnal hemoglobinuria

    Sodium bicarbonate

    【Product name】MEYLON, ZEGERID, OMEPRAZOLE-BICARB

    [English common name]Sodium Bicarbonate

    [Chinese common name]Sodium bicarbonate

    [English name]Baking soda

    [Chinese other name]baking soda

    [indications]
    Children's rhubarb sodium bicarbonate tablets: for indigestion, loss of appetite and acid reflux
    Rhubarb sodium bicarbonate tablets: for appetite deficiency, hyperacidity

    【Dosage】
    Children's rhubarb sodium bicarbonate tablets: oral, 1 to 3 tablets, 3 times a day.
    Rhubarb sodium bicarbonate tablets: Oral, 1 to 3 tablets at a time, 3 times a day.

    [Storage]
    Children's rhubarb sodium bicarbonate tablets: shading, sealed preservation
    Rhubarb sodium bicarbonate tablets: shading, sealed, kept in a cool dry place

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

  • Paroxysmal nocturnal hemoglobinuria

    Aiku group monoclonal antibody

    【Product name】Soliris

    [English common name]Eculizumab

    [Chinese common name]Aiku group monoclonal antibody

    [English name]

    [Chinese other name]Eculizumab

    [Indications] Soliris is a complement inhibitor suitable for:
    (1) T treatmentParoxysmal nocturnal hemoglobinuria(PNH) patients reduce hemolysis.
    (2) treatment of atypical hemolytic uremic syndrome (aHUS) patients with inhibition of complement-mediated thrombotic microangiopathy.

    [Usage and Dosage] The recommended dose is 2 mg / kg intravenously, the minimum range is 3.5 to 4.5 hours, based on the infusion volume, once a week. It is recommended to use antihistamines or no antipyretics for pre-treatment 30 to 60 minutes before the start of the infusion.
    In the case where the solution and container permit, the particulate matter and discoloration of the parenteral drug product should be visually inspected prior to administration.
    The patient is administered a dilute solution using a low protein binding infusion set fitted with a low protein binding 0.2 micron (μm) in-line filter.
    Note: The safety and efficacy of Vimizim has not been determined in pediatric patients of less than 5 years.
    For patients weighing less than 25 kg, the first infusion rate should be 3 mL per minute for 15 minutes, and if it is tolerated, increase to 6 mL per hour for the next 15 minutes. If you tolerate this ratio, the speed can be increased every 15 minutes, 6 ml per hour, no more than 36 ml each time.
    hour. The total infusion should be completed in at least 3.5 hours.
    For patients weighing 25 kg or more, the first infusion rate should be 6 ml per hour for 15 minutes. If it is tolerated, the infusion rate can be increased to 12 mL per hour for the next 15 minutes.
    If this rate is tolerable, the rate can be increased in increments of 12 milliliters per hour for every 15 minutes instead of over 72 milliliters per hour. The total amount of infusion should be delivered for at least 4.5 hours.

    [Storage] Store in the refrigerator (2 ° C – 8 ° C). Do not freeze. Store in original packaging to protect against light.
    The Soliris vial in the original package can be removed from the freezer only once for up to 3 days. At the end of this period, the product can be returned to the refrigerator.

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.