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  • Heparin-induced thrombocytopenia (HIT)

    Lepididine

    【Product name】Refludan

    [English common name]Lepirudin

    [Chinese common name]Lepididine

    [English name]Lepirudin Recombinant

    [Chinese other name]

    [indications]Heparin-induced thrombocytopeniaAnd related thromboembolic diseases to prevent complications.

    [Usage and Dosage] Heparin-induced thrombocytopenia and thromboembolic related diseases. Adult initial dose: 0.4mg/kg, slow intravenous injection at 15-20 seconds; maintenance dose: continuous intravenous infusion of 0.15mg/kg per hour; depending on patient response, generally lasts 2-10 days, longer if needed time. The maximum initial dose was 44 mg and the maximum infusion dose was 16.5 mg/h. Partial thromboplastin time (APTT) was monitored and dose adjusted according to APTT (extending 1.5 to 2.5 times APTT).
    Patients with renal insufficiency should be reduced to avoid dialysis patients.
    According to US and UK recommendations: patients with renal insufficiency, the initial dose is reduced to 0.2 mg / kg, the maintenance dose is adjusted according to creatinine clearance (CCR):
    CCR 45~60ml/min: 75 ug/kg per hour
    CCR 30~45 ml/min: 45 ug/kg per hour
    CCR 15~30ml/min: 22.5 ug/kg per hour
    CCR is less than 15 ml/min to avoid continuous administration. Patients with dialysis and acute renal failure can be injected intravenously 100 ug/kg every other day according to the reaction.

    [Storage]Store unopened vials at 2 to 25 ° C (35.6 to 77 ° F).Use Refludan before the expiration date given on the carton and container.

    [Tips] Some of the information on this site comes from the Internet and is only used internally by pharmacists or medical staff. It is not a substitute for doctors to diagnose face to face. Please consult a professional pharmacist for specific medications. Please refer to the actual product manual or the actual product for the product content.

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